Regular ArticleSonic Hedgehog and FGF8: Inadequate Signals for the Differentiation of a Dopamine Phenotype in Mouse and Human Neurons in Culture
References (38)
- et al.
Multiple signaling pathways direct the initiation of tyrosine hydroxylase gene expression in cultured brain neurons
Mol. Brain Res.
(1997) - et al.
Brain-derived neurotrophic factor works coordinately with partner molecules to initiate tyrosine hydroxylase expression in striatal neurons
Brain Res.
(1995) - et al.
Induction of midbrain dopamine neurons by sonic hedgehog
Neuron
(1995) - et al.
Neruotransmitters, KCl, and antioxidants rescue striatal neurons from apoptotic cell death in culture
Brain Res.
(1999) - et al.
Cellular and molecular treatments of neurological diseases
Exp. Neurol.
(1999) - et al.
Co-expresssion of tyrosine hydroxylase and glutamic acid decarboxylase in dopamine differentiation factor-treated striatal neurons in culture
Dev. Brain Res.
(1996) - et al.
cAMP, an activator of protein kinase A, suppresses the expression of sonic hedgehog
Biochem. Biophys. Res. Commun.
(1996) - et al.
Plasticity and stem cells in the vertebrate nervous system
Curr. Opin. Cell Biol.
(1998) - et al.
Recovery of spatial learning by grafts of a conditionally immortalized hippocampal epithelial cell line into the ischaemia-lesioned hippocampus
Neuroscience
(1997) - et al.
FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate
Cell
(1998)
Retinoic acid induces cholinergic differentiation of Ntera 2 human embryonal carcinoma cells
Int. J. Dev. Neurosci.
Synergy between growth factors and neurotransmitters required for catecholamine differentiation in brain neurons
J. Neurosci.
Protein kinase C activators work in synergy with specific growth factors to initiate tyrosine hydroxylase gene expression in striatal neurons in culture
J. Neurochem.
Novel expression of the tyrosine hydroxylase gene requires both acidic fibroblast growth factor and an activator
J. Neurosci.
Prospects for new restorative and neuroprotective treatments in Parkinson's disease
Nature
Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway
Development
Mammalian neural stem cells
Science
Molecular mechanisms underlying the synergistic induction of tyrosine hydroxylase gene expression by acidic fibroblast growth factor and co-activators
J. Neurosci.
Cited by (33)
Fetal mouse mesencephalic NPCs generate dopaminergic neurons from post-mitotic precursors and maintain long-term neural but not dopaminergic potential in vitro
2012, Brain ResearchCitation Excerpt :In contrast to our data, many research groups failed to produce dopaminergic neurons from murine tissue-specific midbrain NPCs even from short-term expanded NPCs. There are two major differences in our protocols compared to those from other groups: First, we used 3% atmospheric oxygen tension similar to the low physiological oxygen conditions present in the fetal brain (Lee et al., 2001), whereas in other studies the oxygen partial pressure in the cultures was inappropriately high (21%) (Chung et al., 2006b; Stull and Iacovitti, 2001). In our previous studies we showed that low oxygen avoids maturation, senescence and cell death and improves dopaminergic differentiation of murine midbrain NPCs (Milosevic et al., 2005, 2007).
Permanent expression of midbrain dopaminergic neurons traits in differentiated amniotic epithelial cells
2012, Neuroscience LettersCitation Excerpt :FGF8 and Shh are two patterning signals for differentiation of dopaminergic neurons in vivo [2,11]. In spite of the scientific consensus about trophic and inductive effects of FGF8 and Shh on dopaminergic neurons in vivo, there are controversial reports about their effects on ex vivo dopaminergic differentiation of stem cells [18]. These different responses to FGF8 and Shh have been ascribed to the differences among the cells under investigation.
Rapid differentiation of NT2 cells in Sertoli-NT2 cell tissue constructs grown in the rotating wall bioreactor
2004, Brain Research Bulletin
- 1
To whom correspondence should be addressed at Department of Neurology, Thomas Jefferson University Medical College, Suite 501 College Building, 1025 Walnut Street, Philadelphia, PA 19107. Fax: (215) 955-2993. E-mail: [email protected].