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Cholesterol Binding and Cholesterol Transport Proteins: pp 489–508Cite as

Cholesterol and Myelin Biogenesis

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Part of the book series: Subcellular Biochemistry ((SCBI,volume 51))

Abstract

Myelin consists of several layers of tightly compacted membranes wrapped around axons in the nervous system. The main function of myelin is to provide electrical insulation around the axon to ensure the rapid propagation of nerve conduction. As the myelinating glia terminally differentiates, they begin to produce myelin membranes on a remarkable scale. This membrane is unique in its composition being highly enriched in lipids, in particular galactosylceramide and cholesterol. In this review we will summarize the role of cholesterol in myelin biogenesis in the central and peripheral nervous system.

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Authors and Affiliations

  1. Department of Neurogenetics, Max-Planck-Institute for Experimental Medicine, Hermann-Rein-Str. 3, Göttingen, Germany

    Gesine Saher

  2. Max-Planck-Institute for Experimental Medicine, Hermann-Rein-Str. 3, Göttingen, Germany

    Mikael Simons

  3. Department of Neurology, University of Göttingen, Robert-Koch-Str. 40, Göttingen, Germany

    Mikael Simons

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    J. Robin Harris

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Saher, G., Simons, M. (2010). Cholesterol and Myelin Biogenesis. In: Harris, J. (eds) Cholesterol Binding and Cholesterol Transport Proteins:. Subcellular Biochemistry, vol 51. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8622-8_18

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