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Adoptive transfer of experimental allergic neuritis in the immune suppressed host

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Abstract

Experimental allergic neuritis (EAN) was induced in normal and irradiated Lewis rats by passively transferring T cells sensitized to SP-26, a peptide fragment of P2 myelin protein. The recipients became sick 4–8 days post transfer and the degree of disability correlated directly with the dose of T cells. Smaller doses caused demyelination of nerve roots and sciatic nerves and larger doses produced more severe demyelination and significant axonal degeneration. Irradiated recipients developed similar clinical EAN and showed macrophage-mediated demyelination despite severe suppression of the host inflammatory response.

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Supported by a grant from the Muscular Dystrophy Association of Canada

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Hahn, A.F., Feasby, T.E., Lovgren, D. et al. Adoptive transfer of experimental allergic neuritis in the immune suppressed host. Acta Neuropathol 86, 596–601 (1993). https://doi.org/10.1007/BF00294298

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  • DOI: https://doi.org/10.1007/BF00294298

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