Abstract
Experimental allergic neuritis (EAN) was induced in normal and irradiated Lewis rats by passively transferring T cells sensitized to SP-26, a peptide fragment of P2 myelin protein. The recipients became sick 4–8 days post transfer and the degree of disability correlated directly with the dose of T cells. Smaller doses caused demyelination of nerve roots and sciatic nerves and larger doses produced more severe demyelination and significant axonal degeneration. Irradiated recipients developed similar clinical EAN and showed macrophage-mediated demyelination despite severe suppression of the host inflammatory response.
Similar content being viewed by others
References
Arnason B, Chelmicka-Szorc E (1972) Passive transfer of experimental allergic neuritis in Lewis rats by direct injection of sensitized lymphocytes into sciatic nerve. Acta Neuropathol (Berl) 22: 1–6
Ben-Nun A, Wekerle H, Cohen I (1981) The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur J Immunol 11: 195–199
Brosnan CF, Craggs R, King R, Thomas P (1984) Attempts to transfer experimental allergic neuritis with lymphocytes. J Neuroimmunol 6: 373–385
Brosnan J, Selmaj K, Raine CS (1988) Hypothesis: a role for tumour necrosis factor in immune-mediated demyelination and its relevance to multiple sclerosis. J Neuroimmunol 18: 87–94
Brostoff S, Levit S, Powers JV (1977) Induction of experimental allergic neuritis with a peptide from myelin P2 basic protein. Nature 268: 752–753
Cannella B, Cross AH, Raine CS (1990) Upregulation and co-expression of adhesion molecules correlate with relapsing autoimmune demyelination in the central nervous system. J Exp Med 172: 1521–1524
Cross AH, Raine CS (1991) Central nervous system endothelial cell-polymorphonuclear cell interactions during autoimmune demyelination. Am J Pathol 139: 1401–1409
Cross AH, Cannella B, Brosnan CF, Raine CS (1990) Homing to central nervous system vasculature by antigen-specific lymphocytes. I. Localization of 14C-labelled cells during acute, chronic and relapsing experimental allergic encephalomyelitis. Lab Invest 63: 162–170
Cross AH, Cannella B, Brosnan CF, Raine CS (1991) Hypothesis: antigen-specific T cells prime central nervous system endothelium for recruitment of nonspecific inflammatory cells to effect autoimmune demyelination. J Neuroimmunol 33: 237–244
Gilbert JJ, Feasby TE, Hahn AF (1983) Intraneural injection of lymphocytes in experimental allergic neuritis. Acta Neuropathol (Berl) 61: 61–64
Griffin JW, Stoll G, Li CY, Tyor W, Cornblath DR (1990) Macrophage responses in inflammatory demyelinating neuropathies. Ann Neurol 27 [Suppl]: 564–568
Hahn AF, Feasby TE, Gilbert JJ (1985) Blood-nerve barrier studies in experimental allergic neuritis. Acta Neuropathol (Berl) 68: 101–109
Hahn AF, Feasby TE, Steele A, Lovgren D, Berry J (1988) Demyelination and axonal degeneration in Lewis rat experimental allergic neuritis depend on the myelin dosage. Lab Invest 59: 115–125
Hahn AF, Feasby TE, Wilkie L, Lovgren D (1991) P2 peptide induced experimental allergic neuritis: a model to study axonal degeneration. Acta Neuropathol 82: 60–65
Hartung HP, Schäfer B, van der Meide PH, Fierz W, Heininger K, Toyka KV (1990) The role of interferon-γ in the pathogenesis of experimental autoimmune disease of the peripheral nervous system. Ann Neurol 27: 247–257
Hartung HP, Jung S, Stoll G, Zielasek J, Schmidt B, Archelos JJ, Toyka KV (1992) Inflammatory mediators in demyelinating disorders of the CNS and PNS. J Neuroimmunol 40: 197–210
Hartung HP, Archelos JJ, Jung S, Miyasaka M, Toyka KV (1993) Inhibition of experimental autoimmune neuritis by monoclonal antibodies to ICAM-1 and LFA-1. Neurology 43: A395
Heininger K, Schäfer B, Hartung HP, Fierz W, Linington C, Toyka KV (1988) The role of macrophages in experimental autoimmune neuritis induced by a P2-specific T cell line. Ann Neurol 23: 326–331
Hinrichs DJ, Humphres RC (1983) The response of the nude (athymic) rat to actively induced and adoptively transferred experimental allergic encephalomyelitis. J Immunol 131: 4–5
Izumo S, Linington C, Wekerle H, Meyermann R (1985) Morphologic study on experimental allergic neuritis mediated by T cell line specific for bovine P2 protein in Lewis rats. Lab Invest 53: 2: 209–218
Kadlubowski M, Hughes R, Gregson N (1980) Experimental allergic neuritis in the Lewis rat: characterization of the activity of peripheral myelin and its major basic protein P2. Brain Res 184: 439–454
Linington C, Izumo S, Suzuki M, Uyemura K, Meyermann R, Wekerle H (1984) A permanent rat T-cell line that mediates experimental allergic neuritis in the Lewis rat in vivo. J Immunol 133: 1946–1950
Olee T, Powell H, Brostoff S (1990) New minimum length requirement for a T cell epitope for experimental allergic neuritis. J Neuroimmunol 27: 187–190
Olsson T (1992) Cytokines in neuroinflammatory disease: role of myelin autoreactive T cell production of interferon-gamma. J Neuroimmunol 40: 211–218
Raine CS, Cannella B, Duijvestijn AM, Cross AH (1990) Homing to central nervous system vasculature by antigen-specific lymphocytes II. Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination. Lab Invest 63: 476–489
Rostami A, Burns J, Brown M, Rosen J, Zweiman B, Lisak R, Pleasure D (1985) Transfer of experimental allergic neuritis with P2-reactive T-cell lines. Cell Immunol 91: 354–361
Rostami A, Gregorian S, Brown M, Pleasure D (1990) Induction of severe experimental autoimmune neuritis with a synthetic peptide corresponding to the 53–78 amino acid sequence of the myelin P2 protein. J Neuroimmunol 30: 145–151
Ruddle N, Bergman CM, McGrath KM, Lingenhald EG, Grunnet M, Padula SJ, Clark RB (1990) An antibody to lymphotoxin and tumour necrosis factor prevents transfer of experimental allergic encephalomyelitis. J Exp Med 172: 1193–1200
Sakai K, Namikawa T, Kunishita T, Yamanouchi K, Tabira T (1986) Studies of experimental allergic encephalomyelitis by using encephalitogenic T cell lines and clones in euthymic and athymic mico. J Immunol 137: 1527–1531
Schmidt B, Stoll G, van der Meide P, Jung S, Hartung HP (1992) Transient cellular expression of γ-interferon in myelin-induced and T-cell line-mediated experimental autoimmune neuritis. Brain 115: 1633–1646
Sedgwick J, Brostoff S, Mason D (1987) Experimental allergic encephalomyelitis in the absence of a classical delayed-type hypersensitivity reaction. Severe paralytic disease correlated with the presence of interleukin-2 receptor-positive cells infiltrating the central nervous system. J Exp Med 165: 1058–1075
Selmaj K, Raine CS (1988) Tumour necrosis factor mediates myelin and oligodendrocyte damage in vivo. Ann Neurol 23: 339–346
Sobel RA, Mitchell ME, Fondren G (1990) Intercellular adhesion molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system. Am J Pathol 136: 1309–1316
Stoll G, Hartung HP (1992) The role of macrophages in degeneration and immune-mediated demyelination of the peripheral nervous system. Adv Immunol 2: 163–179
Sun D, Meyermann R, Wekerle AH (1988) Cytotoxic T cells in autoimmune disease of the central nervous system. Ann NY Acad Sci 532: 221–229
Tabira T, Sakai K (1987) Demyelination induced by T cell lines and clones specific for myelin basic protein in mice. Lab Invest 56: 518–525
Waksman B, Adams R (1955) Allergic neuritis: an experimental disease of rabbits induced by the injection of peripheral nervous tissue and adjuvants. J Exp Med 102: 213–235
Author information
Authors and Affiliations
Additional information
Supported by a grant from the Muscular Dystrophy Association of Canada
Rights and permissions
About this article
Cite this article
Hahn, A.F., Feasby, T.E., Lovgren, D. et al. Adoptive transfer of experimental allergic neuritis in the immune suppressed host. Acta Neuropathol 86, 596–601 (1993). https://doi.org/10.1007/BF00294298
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00294298