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Diagnosis of cerebral Whipple's disease by cerebrospinal fluid cytology

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Summary

In a case of Whipple's disease the diagnosis was made by careful cytologic evaluation of the cerebrospinal fluid (CSF), identifying “Sieracki cells”. A basal granuloma invaded the hypothalamus, diencephalon, and rostral parts of the brainstem. An exploration in the initial stage led to misdiagnosis as a granular cell tumor. Diagnosis was then confirmed by intestinal biopsy.

Zusammenfassung

Es wird über einen Fall mit Morbus Whipple berichtet, der bei sorgfältiger Untersuchung des Liquor cerebrospinalis durch den Nachweis von Sieracki-Zellen diagnostiziert wurde. Die Exploration eines basalen Granuloms, das in den Hypothalamus, das Diencephalon und die rostralen Anteile des Hirnstamms eingewachsen war, hatte im Frühstadium zur Fehlinterpretation eines Granularzelltumors geführt. Die Diagnose wurde schließlich durch Dünndarmbiopsie bestätigt.

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Wiethölter, H., Dichgans, J. Diagnosis of cerebral Whipple's disease by cerebrospinal fluid cytology. Arch Psychiatr Nervenkr 231, 283–287 (1982). https://doi.org/10.1007/BF00343298

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  • DOI: https://doi.org/10.1007/BF00343298

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