Abstract
Using a specific radioimmunoassay we have measured somatostatinlike immunoreactivity (SLIR) of CSF in patients with brain atrophy, spinal spasticity, seizures, brain tumors and inflammatory disorders.
Patients with marked brain atrophy had significantly decreased somatostatin levels in CSF. In patients with spinal spasticity significantly higher levels were observed. Seizure patients had reduced levels but the difference was not significant. In patients with inflammatory disorders and malignant brain tumors SLIR levels were significantly elevated but not in patients with benign brain tumors. A possible pathophysiologic meaning of SLIR in spasticity and seizures is discussed. The altered levels in brain atrophy, tumors and inflammatory disorders are probably indirect signs of altered somatostatin turnover or increased somatostatin leakage from damaged CNS.
Zusammenfassung
Bei neurologischen Patienten wurde die Immunreaktivität für Somatostatin (SLIR) im Liquor cerebrospinalis mit einem spezifischen Radioimmuntest gemessen. Patienten mit Hirnatrophie hatten signifikant verminderte, Patienten mit spinaler Spastik signifikant erhöhte SLIR-Werte. Auch bei Patienten mit malignen Hirntumoren und mit entzündlichen Prozessen fanden sich erhöhte Werte, während Patienten mit Epilepsie gering und nicht signifikant erniedrigte SLIR-Spiegel hatten. Die mögliche pathophysiologische Bedeutung einer erhöhten Aktivität spinaler somatostatinerger Neurone bei Spastik und Ursachen der Änderungen bei cerebralen Prozessen werden diskutiert.
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Kohler, J., Schröter, E. & Cramer, H. Somatostatin-like immunoreactivity in the cerebrospinal fluid of neurological patients. Arch Psychiatr Nervenkr 231, 503–508 (1982). https://doi.org/10.1007/BF00343993
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DOI: https://doi.org/10.1007/BF00343993