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Increased accumulation of N-isopropyl-p-(123I)-iodoamphetamine in two cases with mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes (MELAS)

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Summary

We present two cases with mitochondrial encephalopathy with lactic acidosis and strokelike episodes (MELAS), which showed both increased and decreased accumulation of N-isopropyl-p-(123I)-iodoamphetamine (123I-IMP) in single photon emission computed tomography (SPECT). The increased accumulation of the tracer occurred, before low density appeared on conventional computed tomography, suggesting that 123I-IMP SPECT may be useful in pathophysiological study of MELAS.

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References

  1. Pavlakis SG, Phillips PC, MiMauro S, De Vivo DC, Rowland LR (1984) Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: A distinctive clinical syndrome. Ann Neurol 16: 481–488

    Google Scholar 

  2. Kuhl DE, Barrio JR, Huang S-C, Selin C, Ackermann RF, Lear JL, Wu JL, Lin TH, Phelps ME (1982) Quantifying local cerebral blood flow by N-isopropyl-p-123I iodoamphetamine (IMP) tomography. J Nucl Med 23: 196–203

    Google Scholar 

  3. Matsuda H, Seki H, Ishida H, Sumiya H, Tsuji S, Hisada K, Fujii H, Yamamoto S, Kobyashi H, Hayashi M (1985) Regional cerebral blood flow measurement using N-isopropyl-p-123I iodoamphetamine and rotating gamma camera emission computed tomography. Jap J Nucl Med 22: 9–18

    Google Scholar 

  4. Shapira Y, Harel S, Russell A (1977) Mitochondrial encephalopathies. A group of neuromuscular disorders with defects in oxidative metabolism. Israel J Med Sci 13: 161–164

    Google Scholar 

  5. Kuriyama M, Umezaki H, Fukuda Y, Osamu M, Koike K, Tateishi J, Igata A (1984) Mitochondrial encephalomyopathy with lactate-pyruvate elevation and brain infarctions. Neurology (Cleveland) 34: 72–77

    Google Scholar 

  6. Kobayashi Y, Miyabayashi S, Takada G, Narisawa K, Toda K, Yamamoto TY (1982) Ultrastructural study of the childhood mitochondrial myopathic syndrome associated with lactic acidosis. Eur J Pediatr 139: 25–30

    Google Scholar 

  7. Yamamoto T, Beppu H, Tsubaki T (1984) Mitochondrial encephalomyopathy: Fluctuating symptoms and CT. Neurology (Cleveland) 34: 1456–1460

    Google Scholar 

  8. Hasuo K, Tamura S, Yasumori K, Uchino A, Goda S, Ishimoto S, Kamikaseda K, Wakuta Y, Kishi M, Masuda K (1987) Computed tomography and angiography in MELAS (Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes); report of 3 cases. Neuroradiology 29: 393–397

    Google Scholar 

  9. Holliday PL, Climie ARW, Gilroy J, Mahmud MZ (1983) Mitochondrial myopathy and encephalopathy: three cases—a deficiency of NADH-CoQ dehydrogenase? Neurology (Cleveland) 33: 1619–1622

    Google Scholar 

  10. Nordström CH, Rehncrona S, Siesjö BK (1978) Restitution of cerebral energy state, as well as of glycolytic metabolites, citric acid cycle intermediates and associated amino acids after 30 minutes of complete ischemia in rats anesthetized with nitrous oxide or phenobarbital. J Neurochem 30: 479–486

    Google Scholar 

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Morita, K., Ono, S., Fukunaga, M. et al. Increased accumulation of N-isopropyl-p-(123I)-iodoamphetamine in two cases with mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes (MELAS). Neuroradiology 31, 358–361 (1989). https://doi.org/10.1007/BF00344185

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  • DOI: https://doi.org/10.1007/BF00344185

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