Abstract
The comparative inhibitory power of organophosphorus esters in vitro against hen brain acetylcholinesterase and neurotoxic esterase correlates with their comparative effects (death or delayed neuropathy) in vivo. Further comparisons of the in vitro effects seen with hen and human enzymes facilitates extrapolations to the human in vivo situation.
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Albert, J. R., Stearns, S. M.: Delayed neurotoxic potential of a series of alkyl esters of 2,2-dichlorovinyl phosphoric acid in the chicken. Toxicol. Appl. Pharmacol. 29, 136 (1974)
Bidstrup, P. L., Bonnell, J. A., Beckett, A. G.: Paralysis following poisoning by a new organic phosphorus insecticide (Mipafox). Br. Med. J. 1953 I, 1068-1072
Durham, W. F., Gaines, T. B., Hayes, W. J.: Paralytic and related effects of certain organic phosphorus compounds. Arch. Ind. Health 13, 326–330 (1956)
Ellman, G. L., Courtney, D. K., Andres, V., Jr., Featherstone, R. M.: A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7, 88–95 (1961)
Fukuhara, N., Hoshi, M., Mori, S.: Core/targetoid fibres and multiple cytoplasmic bodies in organophosphate neuropathy. Acta. Neuropathol. (Berl.) 40, 137–144 (1977)
Hierons, R., Johnson, M. K.: Clinical and lexicological investigations of a case of delayed neuropathy in man after acute poisoning by an organophosphorus pesticide. Arch. Toxicol (Berl.) 40, 279–284 (1978)
Johnson, M. K.: The delayed neurotoxic effect of some organophosphorus compounds: indentification of the phosphorylation site as an esterase. Biochem. J. 114, 711–717 (1969)
Johnson, M. K.: Organophosphorus and other inhibitors of brain “neurotoxic esterase” and the development of delayed neurotoxicity in hens. Biochem. J. 120, 523–531 (1970)
Johnson, M. K.: The primary biochemical lesion leading to the delayed neurotoxic effects of some organophosphorus esters. J. Neurochem. 23, 785–789 (1974)
Johnson, M. K.: The delayed neuropathy caused by some organophosphorus esters: mechanism and challenge. CRC Crit. Rev. Toxicol. 3, 289–316 (1975a)
Johnson, M. K.: Organophosphorus esters causing delayed neurotoxic effects: mechanism of action and structure/activity relationships. Arch. Toxicol. (Berl.) 34, 259–288 (1975b)
Johnson, M. K.: Structure-activity relationships for substrates and inhibitors of hen brain neurotoxic esterase. Biochem. Pharmacol. 24, 797–805 (1975c)
Johnson, M. K..: Improved assay of neurotoxic esterase for screening organophosphates for delayed neurotoxicity potential. Arch. Toxicol. (Berl.) 37, 113–115 (1977)
Johnson, M. K.: The anomalous behaviour of dimethyl phosphates in the biochemical test for delayed neurotoxicity. Arch. Toxicol. (Berl.) 41, 107–110 (1978)
Koelle, G. B.: In: Handbuch der experimentellen Pharmakologie (O. Eichler, A. Farah, Hrsg.), Vol. XV. Berlin-Heidelberg-New York: Springer 1963
Martin, H., Worthing, C. R.: Pesticide manual, 5th Ed. Brit. Crop. Protect. Council (1977)
Pickering, W. R., Malone, J. C.: The acute toxicity of dichloroalkyl aryl phosphates in relation to chemical structure. Biochem. Pharmacol. 16, 1183–1194 (1967)
Smith, H. V., Spalding, J. M. K.: Outbreak of paralysis in Morocco due to ortho-cresyl phosphate poisoning. Lancet 1959 II, 1019–1021
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Visiting worker from Istituto di Medicina del Lavoro. Universita di Padova (Italy)
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Lotti, M., Johnson, M.K. Neurotoxicity of organophosphorus pesticides: predictions can be based on in vitro studies with hen and human enzymes. Arch. Toxicol. 41, 215–221 (1978). https://doi.org/10.1007/BF00354093
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DOI: https://doi.org/10.1007/BF00354093