Abstract
The expression of 17 adhesion molecules was immunohistochemically examined in 5 primary cerebral lymphomas (PCL) and in 5 histologically similar nodal lymphomas (NL) to evaluate their possible involvement in selective targeting of lymphoma cells to the brain. PCL and NL tumor cells showed very similar expression patterns: they were consistently positive for α3, α4 and β1 integrin chains; negative for α2, α6, β3 and β4 integrin chains; and heterogeneous for α5, αL, αM, αX, β2 and β7 integrin chains, as well as for intercellular adhesion molecule-1 (ICAM-1) and the selectin LECAM-1. Loosely infiltrating PCL showed lower levels of the αLβ2 integrin than compact cell clusters. Vessels stained for ICAM-1 and vascular cell adhesion molecule-1 (VCAM-1). We conclude that the adhesion molecules implicated in the extravasation of non-neoplastic leukocytes (α4β1/VCAM-1 and αLβ2/ICAM-1) are also expressed by both PCL and NL. The adhesion molecules examined are apparently not selective mediators of lymphoma cell homing to the brain, but at least αLβ2 integrin might be related to the infiltration pattern of PCL within the brain parenchyma.
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Paulus, W., Jellinger, K. Comparison of integrin adhesion molecules expressed by primary brain lymphomas and nodal lymphomas. Acta Neuropathol 86, 360–364 (1993). https://doi.org/10.1007/BF00369448
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DOI: https://doi.org/10.1007/BF00369448