Summary
Nerve cell counts of the lateral horns of the spinal cord were performed in 15 cases of multiple system atrophy (MSA) and three age-and sexmatched controls. The patients with MSA were comprised of eight with severe postural hypotension, three with orthostatic hypotension and little or no disability and four without any signs of autonomic failure. All cases of MSA had lost more than half their lateral horn cells but nerve cell loss could not be correlated with the degree of dysautonomia. These results confirm the involvement of the intermediolateral columns of the spinal cord in MSA. However, the lack of correlation between cell loss and severity of autonomic failure in our cases, suggests that lesions of other sites, such as sympathetic ganglia or the dorsal vagal nuclei, are also implicated in dysautonomia.
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References
Adams RD, van Bogaert L, Van der Eecken H (1964) Striato-nigral degeneration. J Neuropathol Exp Neurol 23:584–608
Boudin G, Guillard A, Mikol J, Galle P (1976) Dégénérescence striato-nigrique. A propos de l'étude clinique, thérapeutique et anatomique de 2 cas. Rev Neurol (Paris) 132:137–156
Dejerine J, Thomas A (1900) L'atrophie olivo-ponto-cérébelleuse. Nouv Iconogr Salpêtrière 13:330–370
Evans DJ, Lewis PD, Malhotra O, Pallis C (1972) Idiopathic orthostatic hypotensions. J Neurol Sci 17:209–218
Graham JG, Oppenheimer DR (1969) Orthostatic hypotension and nicotine sensitivity in a case of multiple system atrophy. J Neurol Neurosurg Psychiatry 32:28–34
Huang YP, Plaitakis A (1984) Morphological changes of olivopontocerebellar atrophy in computed tomography and comments on its pathogenesis. In: Duvoisin RC, Plaitakis A (eds) The olivopontocerebellar atrophies. Raven Press, New York, pp 39–85
Hughes RC, Cartlidge NEF, Millac P (1970) Primary neurogenic orthostatic hypotension. J Neurol Neurosurg Psychiatry 33:363–371
Jellinger K, Tarnowska-Dziduszko E (1971) Die ZNS-Veränderungen bei den olivo-ponto-cerebellaren Atrophien. Z Neurol 199:192–214
Kennedy PGE, Duchen LW (1985) A quantitative study of intermediolateral column cells in motor neuron disease and the Shy-Drager syndrome. J Neurol Neurosurg Psychiatry 48:1103–1106
Khurana RK, Nelson E, Azzarelli B, Garcia JH (1980) Shy-Drager syndrome: diagnosis and treatment of cholinergic dysfunction. Neurology 30:805–809
Low PA, Thomas JE, Dyck PJ (1978) The splanchnic autonomic outflow in Shy-Drager syndrome and idiopathic orthostatic hypotension. Ann Neurol 4:511–514
Michel D, Tommasi M, Laurent B, Trillet M, Schott B (1976) Dégénérescence striato-nigrique. A propos de deux observations anatomo-cliniques. Rev Neurol (Paris) 132:3–22
Oppenheimer DR (1980) Lateral horn cells in progressive autonomic failure. J Neurol Sci 46:393–404
Oppenheimer DR (1983) Neuropathology of progressive autonomic failure. In: Bannister R (ed) Autonomic failure. A text book of clinical disorders of the autonomic nervous system. Oxford University Press, Oxford pp 266–283
Petilo CK, Black IB (1978) Ultrastructure and biochemistry of sympathetic ganglia in idiopathic orthostatic hypotension. Ann Neurol 4:6–17
Shy GM, Drager GA (1960) A neurological syndrome associated with orthostatic hypotension. Arch Neurol 2:511–527
Sung JH, Mastri AR, Segal E (1979) Pathology of Shy-Drager syndrome. J Neuropathol Exp Neurol 38:353–368
Takei Y, Mirra SS (1973) Striatonigral degeneration, a form of multiple system atrophy with clinical parkinsonism. Prog Neuropathol 2:217–251
Ziegler MG, Lake CR, Kopin IJ (1977) The sympatheticnervous-system defect in primary orthostatic hypotension. N Engl J Med 296:293–297
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Gray, F., Vincent, D. & Hauw, J.J. Quantitative study of lateral horn cells in 15 cases of multiple system atrophy. Acta Neuropathol 75, 513–518 (1988). https://doi.org/10.1007/BF00687140
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DOI: https://doi.org/10.1007/BF00687140