Skip to main content
SpringerLink
Log in

Motor neuron disease and past poliomyelitis

Geographic study in Hokkaido, the Northern-Most Island of Japan

  • Original Communications
  • Published:
Journal of Neurology Aims and scope Submit manuscript

Abstract

We carried out a survey on the cases of motor neuron disease (MND) occurring in Hokkaido between 1980 and 1989 in order to establish whether there is a relationship between MND and poliomyelitis. Hokkaido, the northern-most island of Japan, was one of the most affected areas during the poliomyelitis epidemic of the late 1940s to 1950s. We ascertained 389 cases of MND for these 10 years and 2,171 cases of paralytic poliomyelitis for the period 1949–1958, and analysed their geographic distributions. No significant correlation was found between MND and poliomyelitis in their geographic distributions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Armon C, Daube JR, Windebank AJ, Kurland LT (1990) How frequently does classic amyotrophic lateral sclerosis develop in survivors of poliomyelitis? Neurology 40:172–174

    Google Scholar 

  2. Iwanaga S, Tokisada A, Kobayashi N, Hyodo T, Nakagawa I, Chiba S, Hamamoto O, Kawamura S (1960) Epidemiological investigation of poliomyelitis in Hokkaido. Rep Hokkaido Inst Publ Health 11:43–48

    Google Scholar 

  3. Kono R (1960) Poliomyelitis in Japan. Ann Rep Inst Virus Res Kyoto Univ 3:1–41

    Google Scholar 

  4. Lilienfeld DE, Chad E, Ehland J, Godbold J, Landrigan PJ, Marsh G, Perl DP (1989) Rising mortality from motorneuron disease in the USA, 1962–83. Lancet I:710–713

    Google Scholar 

  5. Martyn CN (1990) Poliovirus and motor neuron disease. J Neurol 237:336–338

    Google Scholar 

  6. Martyn CN, Barker DJP, Osmond C (1988) Motorneuron disease and past poliomyelitis in England and Wales. Lancet I:1319–1322

    Google Scholar 

  7. Miller JR (1982) Persistent infection by poliovirus: experimental studies. In: Rowland LP (ed) Human motor neuron diseases. Raven Press, New York, pp 311–316

    Google Scholar 

  8. Mitsumoto H, Hanson MR, Chad DA (1988) Amyotrophic lateral sclerosis. Recent advances in pathogenesis and therapeutic trials. Arch Neurol 45:189–202

    Google Scholar 

  9. Moriwaka F, Tashiro K, Okumura H, Yamada T (1991) ALS and poliomyelitis. Neurology 41:612

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology, Hokkaido University School of Medicine, North 14, West 5, Kita-ku, 060, Sapporo, Japan

    F. Moriwaka, H. Okumura & K. Tashiro

  2. Hokuyukai Neurological Hospital, Sapporo, Japan

    T. Hamada

  3. Department of Neurology, National Sapporo Minami Hospital, Sapporo, Japan

    A. Matsumoto

  4. Department of Neurology, Sapporo Medical College, Sapporo, Japan

    H. Matsumoto

  5. Department of Neurology and Psychiatry, Sapporo Medical College, Sapporo, Japan

    N. Takahata

  6. Department of Neurology, Nakamura Memorial Hospital, Sapporo, Japan

    N. Itoh

  7. Department of Neurology, Sapporo City Hospital, Sapporo, Japan

    R. Shindo

Authors
  1. F. Moriwaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Okumura
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. Tashiro
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. Hamada
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. Matsumoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. H. Matsumoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. N. Itoh
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. R. Shindo
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. N. Takahata
    View author publications

    You can also search for this author in PubMed Google Scholar

Consortia

ALS Study Group

Rights and permissions

Reprints and permissions

About this article

Cite this article

Moriwaka, F., Okumura, H., Tashiro, K. et al. Motor neuron disease and past poliomyelitis. J Neurol 240, 13–16 (1993). https://doi.org/10.1007/BF00838439

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00838439

Key words

Search

Navigation