Skip to main content
SpringerLink
Log in

Effect of sleep deprivation on dopamine receptor function in normal subjects

  • Published:
Journal of Neural Transmission Aims and scope Submit manuscript

Summary

Twenty-four hours sleep deprivation significantly decreased the growth hormone response to the dopamine receptor agonist, apomorphine HCl, in five normal men (0.5 mg s.c.) and one woman (0.75 mg s.c.) but had no effect on basal or post-apomorphine prolactin concentrations. These results suggest that sleep deprivation decreases the sensitivity of certain central dopamine receptors. The relevance of this finding to the antidepressant effect of sleep deprivation is unclear.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Beck, U., Marquetand, D. Effects of selective sleep deprivation on sleeplinked prolactin and growth hormone secretion. Arch. Psychiat. Nervenkr.223, 35–44 (1976).

    PubMed  Google Scholar 

  • Bhanji, S., Roy, G. A. The treatment of psychotic depression by sleep deprivation. A replication study. Brit. J. Psychiat.127, 222–226 (1975).

    PubMed  Google Scholar 

  • Ettigi, P., Lal, S., Martin, J. B., Friesen, H. G. Effect of sex, oral contraceptives and glucose loading on apomorphine-induced growth hormone secretion. J. Clin. Endocr. Metab.40, 1094–1098 (1975).

    PubMed  Google Scholar 

  • Ferguson, J., Dement, W. The behavioral effects of amphetamine in REM deprived rats. J. Psychiat. Res.7, 111–118 (1969).

    PubMed  Google Scholar 

  • Friesen, H. G., Guyda, H., Hardy, J. Biosynthesis of human growth hormone and prolactin. J. Clin. Endocr. Metab.31, 611–624 (1970).

    Google Scholar 

  • Gerner, R. H., Post, R. M., Bunney, W. E. A dopaminergic mechanism in mania. Amer. J. Psychiat.133, 1177–1180 (1976).

    PubMed  Google Scholar 

  • Gerner, R. H., Post, R. M., Gillin, J. C., Bunney, W. E. Biological and behavioral effects of one night's sleep deprivation in depressed patients and normals. J. Psychiat. Res.15, 21–40 (1979).

    PubMed  Google Scholar 

  • Ghosh, P., Hrdina, P. D., Ling, G. M. Effects of REMS deprivation on striatal dopamine and acetylcholine in rats. Pharmacol. Biochem. Behav.4, 401–405 (1970).

    Google Scholar 

  • Hartmann, E., Orzack, M. H., Branconnier, P. Sleep deprivation deficits and their reversal by d- and l-amphetamine. Psychopharmacol.53, 185–189 (1977).

    Google Scholar 

  • Hwang, P., Guyda, H., Friesen, H. A radioimmunoassay for human prolactin. Proc. Nat. Acad. Sci. (Wash.)68, 1902–1906 (1971).

    Google Scholar 

  • Jacoby, J. H., Smith, E., Sassin, J. F., Greenstein, M., Weitzman, E. D. Altered growth hormone secretory pattern following prolonged sleep deprivation in the rhesus monkey. Neuroendocrinology18, 9–15 (1975).

    PubMed  Google Scholar 

  • Karacan, I., Rosenbloom, A. L., Williams, R. L., Finley, W. W., Hursch, C. J. Slow wave sleep deprivation in relation to plasma growth hormone concentration. Behav. Neuropsychol.2, 11–14 (1971).

    Google Scholar 

  • Koranyi, E. K., Lehmann, H. E. Experimental sleep deprivation in schizophrenic patients. Arch. Gen. Psychiat.2, 534–544 (1960).

    PubMed  Google Scholar 

  • Korf, J., Van Praag, J. M. Retarded depression and dopamine metabolism. Psychopharmacologia (Berl.)19, 199–203 (1971).

    Google Scholar 

  • Lal, S., Nair, N. P. V.: Growth Hormone and Prolactin Responses in Neuropsychiatric Research. In: Neuroendocrinc Correlates in Neurology and Psychiatry (Müller, E. E., Agnoli, A., eds.), pp. 179–194. Elsevier/North Holland Biomedical Press. 1979.

  • Lal, S., de la Vega, C. E., Sourkes, T. L., Friesen, H. G. Effect of apomorphine on human-growth-hormone secretion. Lancet2, 661 (1972).

    Google Scholar 

  • Lal, S., de la Vega, C. E., Sourkes, T. L., Friesen, H. G. Effect of apomorphine on growth hormone, prolactin, luteinizing hormone and follicle-stimulating hormone levels in human serum. J. Clin. Endocr.37, 719–724 (1973).

    PubMed  Google Scholar 

  • Lal, S., Guyda, H., Bikadoroff, S. Effect of methysergide and pimozide on apomorphine-induced growth hormone secretion in men. J. Clin. Endocr. Metab.44, 766–770 (1977).

    PubMed  Google Scholar 

  • Larsen, J. K., Lindberg, M. L., Skovgaard, B. Sleep deprivation as treatment for endogenous depression. Acta Psychiat. Scand.54, 167–173 (1976).

    PubMed  Google Scholar 

  • Livrea, P., DiReda, L., Puca, F. M., Genco, S., Specchio, L. M., Papagno, G. Homovanillic acid and 5-hydroxyindoleacetic acid in lumbar cerebrospinal fluid after total and REM sleep deprivation in humans. Europ. Neurol.16, 280–285 (1977).

    PubMed  Google Scholar 

  • Luby, E. D., Caldwell, D. F. Sleep deprivation and EEG slow wave activity in chronic schizophrenia. Arch. Gen. Psychiat.17, 361–364 (1967).

    PubMed  Google Scholar 

  • Martin, J. B., Lal, S., Tolis, G., Friesen, H. G. Inhibition by apomorphine of prolactin secretion in patients with elevated serum prolactin. J. Clin. Endocr. Metab.39, 180–182 (1974).

    PubMed  Google Scholar 

  • Murphy, D. L., Goodwin, F. K., Brodie, H. K. H., Bunney, W. E. L-Dopa, dopamine and hypomania. Am. J. Psychiat.130, 79–82 (1973).

    PubMed  Google Scholar 

  • Nair, N. P. V., Lal, S., Cervantes, P., Yassa, R., Guyda, H. Effect of clozapine on apomorphine-induced growth hormone secretion and serum prolactin concentrations in schizophrenia. Neuropsychobiology5, 136–142 (1979).

    PubMed  Google Scholar 

  • Pflug, B. The influence of sleep deprivation on the duration of endogenous depressive episodes. Arch. Psychiat. Nervenkr.225, 173–177 (1978).

    PubMed  Google Scholar 

  • Post, R. M., Kotin, J., Goodwin, F. K. Effects of sleep deprivation on mood and central amine metabolism in depressed patients. Arch. Gen. Psychiat.33, 627–632 (1976).

    PubMed  Google Scholar 

  • Post, R. M., Gerner, R. H., Carman, J. S., Gillin, J. C., Jimerson, D. C., Goodwin, F. K., Bunney, W. E. Effects of a dopamine agonist piribedil in depressed patients: relationship of pretreatment HVA to antidepressant response. Arch. Gen. Psychiat.35, 609–615 (1978).

    PubMed  Google Scholar 

  • Sassin, J. F., Parker, D. C., Johnson, L. C., Rossman, L. G., Mace, J. W., Gotlin, K. W. Effects of slow wave sleep deprivation on human growth hormone release in sleep. Preliminary study. Life Sci.8, 1299–1307 (1969).

    Google Scholar 

  • Sinha, A. K., Ciaranello, R. D., Dement, W. C., Barchas, J. D. Tyrosine hydroxylase activity in rat brain following “REM” sleep deprivation. J. Neurochem.20, 1289–1290 (1973).

    PubMed  Google Scholar 

  • Sourkes, T. L., Lal, S. Apomorphine and its relation to dopamine in the nervous system. Adv. Neurochem.1, 247–299 (1975).

    Google Scholar 

  • Svendsen, K. Sleep deprivation therapy in depression. Acta Psychiat. Scand.54, 184–192 (1976).

    PubMed  Google Scholar 

  • Tsang, D., Lal, S. Effect of monoamine receptor agonists and antagonists on cyclic AMP accumulation in human cerebral cortex slices. Canad. J. Physiol. Pharmacol.55, 1263–1269 (1977).

    Google Scholar 

  • Tufik, S., Lindsey, C. J., Carlini, E. A. Does REM sleep deprivation induce a supersensitivity of dopaminergic receptors in the rat brain? Pharmacology16, 98–105 (1978).

    PubMed  Google Scholar 

  • Van Praag, H. M., Korf, J., Schut, T. Cerebral monoamines and depression. An investigation with the probenecid technique. Arch. Gen. Psychiat.28, 827–831 (1973).

    PubMed  Google Scholar 

  • Van Scheyen, J. D., Van Praag, H. M., Korf, J. Controlled study comparing nomifensine and cloimipramine in unipolar depression, using the probenecid technique. Br. J. Clin. Pharmac.4, 1795–1845 (1977).

    Google Scholar 

  • Vogel, G. W., Thurmond, A., Gibbons, P., Sloan, K., Boyd, M., Walker, M. REM sleep reduction effects on depression syndromes. Arch. Gen. Psychiat.32, 765–777 (1975).

    PubMed  Google Scholar 

Download references

Author information

Author notes

  1. S. Lal

    Present address: Department of Psychiatry, McGill University, Douglas Hospital Centre, Montreal General Hospital, Canada

Authors and Affiliations

  1. Department of Psychiatry, McGill University, Douglas Hospital Centre, Montreal General Hospital, Canada

    J. Thavundayil, N. P. V. Nair, P. Etienne, R. Rastogi, G. Schwartz, J. Pulman & H. Guyda

  2. Protein and Polypeptide Laboratory, Montreal, Canada

    S. Lal, J. Thavundayil, N. P. V. Nair, P. Etienne, R. Rastogi, G. Schwartz, J. Pulman & H. Guyda

Authors
  1. S. Lal
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Thavundayil
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. P. V. Nair
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. Etienne
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R. Rastogi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. G. Schwartz
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. J. Pulman
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. H. Guyda
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lal, S., Thavundayil, J., Nair, N.P.V. et al. Effect of sleep deprivation on dopamine receptor function in normal subjects. J. Neural Transmission 50, 39–45 (1981). https://doi.org/10.1007/BF01254912

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01254912

Keywords

Search

Navigation