Abstract
This is the first prospective study of adverse reactions occurring in primary-antibody-deficient patients self-infusing intravenous immunoglobulin at home. One hundred nineteen patients, already self-infusing at home, were entered into the study. They had been fully instructed about all aspects of adverse reactions, including their prevention and treatment. In the event of any adverse reaction, a form was completed detailing the product, the dose, the symptoms that occurred and the time they lasted, the rate of infusion, and other relative information such as predisposing factors and any medication taken. The severity of reactions were classified as mild, moderate, or severe. The total number of reactions documented was 19 in 2031 infusions, and all resolved without medical aid. No serious reactions occurred. Excluding those reactions in which predisposing factors were identified, the overall reaction rate was 0.7%. In conclusion the study showed the reaction rate in patients self-infusing intravenous immunoglobulin at home was low following formal training of selected patients at recognized training centers.
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References
Garbett ND, Currie DC, Cole PJ: Comparison of the clinical efficacy and safety of an intramuscular and an intravenous immunoglobulin preparation for replacement therapy in idiopathic adult onset panhypogammaglobulinaemia. Clin Exp Immunol 76:1–7, 1989
Cunningham-Rundles C: Clinical and immunologic analysis of 103 patients with common variable immunodeficiency. J Clin Immunol 9:22–33, 1989
Ochs HD, Lee ML, Fischer SA, Delson ES, Chang BS, Wedgwood RJ: Self-infusion of intravenous immunoglobulin by immunodeficient patients at home. J Infect Dis 156:652–654, 1987
Chapel H, Brennan V, Delson E: Immunoglobulin replacement therapy by self-infusion at home. J Clin Immunol 73:160–162, 1988
Misbah SA, Chapel H: Adverse effects of intravenous immunoglobulin. Drug Safety 9(4):252–262, 1993
Bjorkander J, Hammarstrom L, Smith CIE, Buckley R, Cunningham-Rundles C, Hanson LA: Successful immunoglobulin prophylaxis in patients with antibody deficiency syndromes in the presence of anti-IgA. J Clin Immunol 7:8–15, 1987
Buckley H, Schiff R: The use of intravenous immune globulin in immunodeficiency diseases. N Engl J Med 325(2):110–116, 1991
Hammarstrom L, Smith CIE: Anaphylaxis after administration of gamma globulin for hypogammaglobulinaemia. N Engl J Med 315:519, 1986
Cunningham-Rundles C, Zhou Z, Mankarious S: Long term use of IgA-depleted intravenous immunoglobulin in immunedeficient subjects with anti-IgA antibodies. J Clin Immunol 13:272–278, 1993
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Brennan, V.M., Cochrane, S., Fletcher, C. et al. Surveillance of adverse reactions in patients self-infusing intravenous immunoglobulin at home. J Clin Immunol 15, 116–119 (1995). https://doi.org/10.1007/BF01541739
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DOI: https://doi.org/10.1007/BF01541739