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Successful response to alpha-interferon 2b in a refractory IgM autoagglutinin-mediated hemolytic anemia

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Summary

We describe the beneficial effect of recombinant alpha 2b interferon in a woman with an idiopathic and refractory IgM-mediated autoimmune hemolytic anemia due to low-titer, high-thermal-amplitude cold agglutinins. The response was partial but sustained, 2 months after interruption of interferon, with hemoglobin concentrations ranging between 8.5 and 10 g/dl. In the literature, such rarely encountered hemolyzing warm-reacting agglutinins are described as causing severe hemolysis with a frequently fatal clinical outcome.

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References

  1. Freedman J, Wright J, Lim FC, Garvey MB (1987) Hemolytic warm IgM autoagglutinins in autoimmune hemolytic anemia. Transfusion 27:464–467

    PubMed  Google Scholar 

  2. O'Connor BM, Clifford JS, Lawrence WD, Logue GL (1989) Alpha-interferon for severe cold agglutinin disease. Ann Intern Med 111:255–256

    PubMed  Google Scholar 

  3. Petz LD (1993) Laboratory evaluation of acquired hemolytic anemias. In: Bick RL (ed) Hematology clinical and laboratory practice. Mosby, Saint-Louis, pp 409–417

    Google Scholar 

  4. Petz LD, Garraty G (1980) Acquired immune hemolytic anemias. Churchill-Livingstone, New York

    Google Scholar 

  5. Shirey RS, Kickler TS, Bell W, Little B, Smith B, Ness PM (1987) Fatal immune hemolytic anemia and hepatic failure associated with a warm-reacting IgM autoantibody. Vox Sang 52:219–222

    PubMed  Google Scholar 

  6. Silberstein LE, Robertson GA, Harris AC, Moreau L, Besa E, Nowell PC (1986) Etiologic aspects of cold agglutinin disease: evidence for cytogenetically defined clones of lymphoid cells and demonstration that an anti-Pr cold autoantibody is derived from a chromosomally aberrant B-cell clone. Blood 67:1705–1709

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Service de Médecine Interne et d'Immunologie Clinique, CHU Jean Minjoz, F-25030, Besançon, France

    T. Fest, B. de Wazières, M. Maskani, D. Vuitton & J. L. Dupond

  2. Regional Blood Transfusion Center, University Hospital of Besançon, F-25030, Besançon, France

    B. Lamy

Authors
  1. T. Fest
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  2. B. de Wazières
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  3. B. Lamy
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  4. M. Maskani
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  5. D. Vuitton
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  6. J. L. Dupond
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Fest, T., de Wazières, B., Lamy, B. et al. Successful response to alpha-interferon 2b in a refractory IgM autoagglutinin-mediated hemolytic anemia. Ann Hematol 69, 147–149 (1994). https://doi.org/10.1007/BF01695696

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  • DOI: https://doi.org/10.1007/BF01695696

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