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HLA and prognosis in multiple sclerosis

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Abstract

The patients of a multiple sclerosis (MS) incidence cohort with 25 years of longitudinal follow-up were typed for HLA-DR and DQ. This type of cohort provides reliable data for gene frequencies and prognostic studies. The influence of sampling bias, mainly due to mortality during the long follow-up, was accounted for. A positive association between MS and DR15,DQ6 was confirmed, but this haplotype did not influence prognosis. There was no difference in haplotype frequency between relapsing-remitting and primary chronic progressive MS. DR17,DQ2 was significantly over-represented in the quartile with the most malignant course. The haplotype DR1,DQ5, which was found rather less frequently in MS patients, also tended to be associated with a poorer prognosis.

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Authors and Affiliations

  1. Department of Neurology, Sahlgren's Hospital, S-413 45, Göteborg, Sweden

    Björn Runmarker & Oluf Andersen

  2. Department of Clinical Genetics, Östra Sjukhuset, Göteborg, Sweden

    Tommy Martinsson & Jan Wahlström

Authors
  1. Björn Runmarker
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  2. Tommy Martinsson
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  3. Jan Wahlström
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  4. Oluf Andersen
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Runmarker, B., Martinsson, T., Wahlström, J. et al. HLA and prognosis in multiple sclerosis. J Neurol 241, 385–390 (1994). https://doi.org/10.1007/BF02033356

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  • DOI: https://doi.org/10.1007/BF02033356

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