Abstract
Discrimination between senile dementia Alzheimer type (SDAT) patients (N=30) and Normal Controls (N=60) by means of a 6-test set was assessed. Performances on Word Fluency (FL), Memory for Prose (PM) and Finger Agnosia (FA) nearly exhaust the discriminant power of the whole battery, including Constructional Apraxia (CA), Token Test (TT) and Weigl's Sorting Test (WT). The battery, however, leaves some facets of the difference between SDAT patients and Controls unexplored, misclassifying almost 20% of the SDAT patients and 10% of the Controls. We emphasize the role of discriminant analysis in the evaluation of any neuropsychological battery of tests which has to be used for diagnostic purposes.
Sommario
È stata studiata la diagnosi differenziale tra dementi tipo Alzheimer (N=30) e Controlli (N=60) per mezzo di tecniche statistiche di Analisi Discriminante. I punteggi di Fluenza Verbale (FL), Memoria di Prosa (PM) e Agnosia Digitale (FA) sono stati sufficienti a saturare il potere discriminante di tutta la Batteria, che comprendeva anche Aprassia Costruttice (CA) Token Test (TT) e Test di Weigh (WT). La batteria lascia tuttavia scoperti alcuni aspetti della differenza tra i due gruppi, in quanto 20% dei soggetti non sono classificati correttamente. Viene illustrata l'importanza dell'Analisi Discriminante al fine di poter ottimizzare la composizione di batterie neuropsicologiche aventi finalità diagnostiche.
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References
Arrigoni C., De Renzi E.:Constructional Apraxia and hemispheric locus of lesions. Cortex 1, 170–197, 1964.
Benton A.L.:The neuropsychological significance of finger recognition. In: Cognitive growth and development. (Eds.: M. Bortuer), Brunec-Mazel, New York, 1979a.
Benton A.L.:Visuospatial and visuoconstructive disorders. In: Clinical Neuropsychology (Eds: K. Heilman et al.) Oxford Univ. Press, New York, 1979b.
Benton A.L., Varaney M.R., Hamshen K. de S.:Visuo-spatial judgement: a clinical test. Arch. Neurol. 35, 364–367, 1978.
Bmdp:University of California Press, P-series: 711–733, 1979.
Chase T.N.:Focal cortical abnormalities in Alzheimer's disease as determined by positron emission tomography. In: Proceed. III Meeting Intern. St. Group Treat. Mem. Dis. Assoc. Aging pp: 95–100, 1984.
Critchley Mc.D.:The Parietal Lobes. Arnold, London, 1953.
Crystal H.A., Horoupian D.S., Katzman R.:Biopsy-proved Alzheimer disease presenting as a right parietal lobe syndrome. Ann. Neurol. 12, 186–188, 1982.
De Renzi E., Faglioni P.:Normative data and screening power of a shortened version of the Token Test. Cortex 14, 41–49, 1978.
De Renzi E., Faglioni P., Savoiardo F., Vignolo L.A.:The influence of aphasia and of hemispheric side of cerebral lesions on abstract thinking. Cortex 2, 399–420, 1966.
De Renzi E., Vignolo L.A.:The Token Test: a sensitive test to detect receptive disturbances in aphasia. Brain 85:665–678, 1962.
De Renzi E., Vignolo L.A.:I disturbi del linguaggio nei dementi. Lav. Neuropsichiat. 12, 1–18, 1965.
De Renzi E., Scotti G., Spinnler H.:Perceptual and associative disorders of visual recognition. Neurology 19, 634–642, 1969.
Irigary L.:Approche psycholinguistique du langage des déments. Neuropsychologie 5, 25–52, 1967.
Kirshner H.S., Webb G.N., Kelly M.P., Wells C.E.:Language disturbances. An initial symptom of cortical degenerations and dementia. Arch. Neurol. 41, 491–496, 1984.
Oldfield R.C.:The assessment and Analysis of Handedness: The Edinburgh Inventory. Neuropsychologia 9, 97–113, 1971.
Sim A., Sussman Z.:Alzheimer's disease: its natural history and differential diagnosis. Nerv. Ment. Dis. 135, 489–499, 1962.
Sjoegren T., Sjogren H., Lindgren A.G.H.:Morbus Alzheimer and morbus Pick. A genetic, clinic and pathoanatomic study. Acta Psychiat. Neurol. Scand. 82 (suppl), 185–194, 1974.
Spinnler H.:Il decadimento demenziale: inquadramento neurologico e neuropsicologico. Pensiero Scientifico, Roma, 1984.
Stengel E.:Disorders of speech and mental disorders. In: Disorders of language (CIBA Foundation) (Eds: A.V. De Reuck et al.) Churchill, London, 1964.
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Bandera, R., Capitani, E., Della Sala, S. et al. Discrimination between senile dementia alzheimer type patients and-education matched normal controls by means of a 6-test set. Ital J Neuro Sci 6, 339–344 (1985). https://doi.org/10.1007/BF02232012
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DOI: https://doi.org/10.1007/BF02232012