Abstract
Irregularly structured brain tumors, such as glioblastomas, challenge attempts to visualize and quantify their three-dimensional structure. Magnetic resonance imaging (MRI) represents one tool for attempting to noninvasively track tumor size. MR images demonstrate widely varying perceived tumor margins. In addition, adjunct therapies, such as the administration of steroids, greatly affect the volumes perceived in images formed by certain pulse sequences. In this study tumors were grown in 15 dogs and the tumor size tracked for a period of time. The dogs were placed on dexamethasone for a week and another series of scans was obtained. No other therapies were provided. The data for visualized tumor size are provided for T1, T2, and proton density. Weighted images are provided and the relationships between the scans are discussed.
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Burger, P.C. Pathologic anatomy and CT correlations in the glioblastoma multiforme. App. Neurophysiol. 46:180–187; 1983.
Dickman, C.A.; Rekate, H.L.; Bird, C.R.; Drayer, B.P.; Medina, M. Unenhanced and gadolinium-DTPA-enhanced MR imaging in postoperative evaluation in pediatric brain tumors. J. Neurosurg. 71:49–53; 1989.
Drayer, B.P.; Muraki, A.; Osborne, D.; Kornegay, J. Gd-DTPA-enhanced magnetic resonance imaging for study of blood-brain-barrier permeability in naturally occurring and experimentally induced brain infarction. In: Runge, V.R.; Claussen, C.; Felix, R.; James, A.E., eds. Contrast agents in magnetic resonance imaging. Amsterdam: Excerpta Medica. 1986: pp. 114–117.
Elster, A.D.; Jackels, S.C.; Allen, N.S.; Marrache, R.C. Europium-DTPA: A gadolinium analogue traceable by fluorescence microscopy. AJNR. 10:1137–1144; 1989.
Form 921. Institutional response for the Children's Cancer Study Group.
Galloway, Jr., R.L.; Collins, J.C. PIPER—An interactive MRI analysis program. Federation Proceedings. 45(3):169; 1986.
Galloway, Jr., R.L.; Maciunas, R.J.; Failinger, A.L.; Whelan, H.T. Volumetric measurement of canine gliomas using MRI. Magnetic Resonance Imaging. 8:161–165; 1990.
Jarden, J.O.; Dhawan, V.; Moeller, J.R.; Strother, S.C.; Rottenberg, D.A. The time course of steroid action on blood-to-brain and blood-to-tumor transport of82Rb; a positron emission tomographic study. Ann. Neurol. 25(3): 239; 1989.
Kelly, P.J.; Daumas-Duport, C.; Scheithauer, B.W.; Kall, B.A.; Kispert, D.W. Stereotactic histologic correlations of computed tomography-and magnetic resonance imagingdefined abnormalities in patients with glial neoplasms. Mayo Clin. Proc. 62:450–459; 1987.
Niedorf, H.P.; Laniado, M.; Semmler, W.; Schorner, W.; Felix, R. Dose administration of gadolinium-DTPA in MR imaging of intracranial tumors. AJNR. 8:803–815; 1987.
Plante, E.; Turkstra, L. Sources of error in quantitative analysis of MRI scans. Magnetic Resonance Imaging. 9:589–595; 1991.
Rabotti, G.F.; Grove, A.S.; Sellers, R.L.; Anderson, W.R. Induction of multiple brain tumors (gliomata and leptomeningeal sarcoma) in dogs by Rouse sarcoma virus. Nature. 209:884–886; 1966.
Wodinsky, I.; Kensler, C.J.; Rall, D.P. Induction and transplantation of brain tumors in neonatal beagles. Proc. Am. Assoc. Cancer Res. 10:99; 1969.
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Galloway, R.L., Maciunas, R.J. & Failinger, A.L. Factors affecting perceived tumor volumes in magnetic resonance imaging. Ann Biomed Eng 21, 367–375 (1993). https://doi.org/10.1007/BF02368629
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DOI: https://doi.org/10.1007/BF02368629