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Esophageal Manometric Abnormalities in Parkinson's Disease

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Abstract.

The gastrointestinal tract, and especially the esophagus, is frequently involved in neurological diseases; however, objective studies of gut motor function are few. We carried out an esophageal manometric study in 18 patients with various stages of Parkinson's disease (4 stage I, 4 stage II, 7 stage III, and 3 stage IV) to evaluate the function of the viscus in this disease. Clinical assessment showed that 61% complained of esophageal symptoms such as dysphagia, acid regurgitation, pyrosis, and noncardiac chest pain. Manometric abnormalities were documented also in 61% patients, and were represented by repetitive contractions, simultaneous contractions, reduced LES pressure, and high-amplitude contractions. However, only 33.3% of patients had both symptoms and manometric abnormalities. We conclude that esophageal motor abnormalities are frequent in Parkinson's disease, and may appear at an early stage of the disease.

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Bassotti, G., Germani, U., Pagliaricci, S. et al. Esophageal Manometric Abnormalities in Parkinson's Disease. Dysphagia 13, 28–31 (1998). https://doi.org/10.1007/PL00009546

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  • DOI: https://doi.org/10.1007/PL00009546

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