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Brain SPET perfusion in early Alzheimer’s disease: where to look?

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References

  1. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 1984; 34:939–944.

    Article  CAS  PubMed  Google Scholar 

  2. Khachaturian ZS. Diagnosis of Alzheimer’s disease. Arch Neurol 1985; 42:1097–1105.

    Article  CAS  PubMed  Google Scholar 

  3. Tierney MC, Reid DW, Zorzitto ML, Snow WG, Fisher RH, Campbell-Taylor I, Lewis A. The differential diagnosis of Alzheimer’s disease: conceptual and methodological issues. Can J Neurol Sci 1986; 13:424–426.

    CAS  PubMed  Google Scholar 

  4. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L. The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer’s disease. Neurology 1991; 41:479–486.

    Article  CAS  PubMed  Google Scholar 

  5. Blacker D, Albert MS, Bassett SS, Go RC, Harrell LE, Folstein MF. Reliability and validity of NINCDS-ADRDA criteria for Alzheimer’s disease. The National Institute of Mental Health Genetics Initiative. Arch Neurol 1994; 51:1198–1204.

    Article  CAS  PubMed  Google Scholar 

  6. Holmes C, Cairns N, Lantos P, Mann A. Validity of current clinical criteria for Alzheimer’s disease, vascular dementia and dementia with Lewy bodies. Br J Psychiatry 1999; 174:45–50.

    Article  CAS  PubMed  Google Scholar 

  7. Jobst KA, Barnetson LP, Shepstone BJ. Accurate prediction of histologically confirmed Alzheimer’s disease and the differential diagnosis of dementia: the use of NINCDS-ADRDA and DSM-III-R criteria, SPECT, X-ray CT, and Apo E4 in medial temporal lobe dementias. Oxford Project to Investigate Memory and Aging. Int Psychogeriatr 1998; 10:271–302.

    Article  CAS  PubMed  Google Scholar 

  8. Lim A, Tsuang D, Kukull W, Nochlin D, Leverenz J, McCormick W, Bowen J, Teri L, Thompson J, Peskind ER, Raskind M, Larson EB. Clinico-neuropathological correlation of Alzheimer’s disease in a community-based case series. J Am Geriatr Soc 1999; 47:564–569.

    CAS  PubMed  Google Scholar 

  9. Victoroff J, Mack WJ, Lyness SA, Chui HC. Multicenter clinicopathological correlation in dementia. Am J Psychiatry 1995; 152:1476–1484.

    CAS  PubMed  Google Scholar 

  10. Gearing M, Mirra SS, Hedreen JC, Sumi SM, Hansen LA, Heyman A. The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). Part X. Neuropathology confirmation of the clinical diagnosis of Alzheimer’s disease. Neurology 1995; 45:461–466.

    Article  CAS  PubMed  Google Scholar 

  11. Massoud F, Devi G, Stern Y, Lawton A, Goldman JE, Liu Y, Chin SS, Mayeux R. A clinicopathological comparison of community-based and clinic-based cohorts of patients with dementia. Arch Neurol 1999; 56:1368–1373.

    Article  CAS  PubMed  Google Scholar 

  12. Anonymous Assessment of brain SPECT. Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 1996; 46:278–285.

    Article  Google Scholar 

  13. Knopman DS, DeKosky ST, Cummings JL, Chui H, Corey- Bloom J, Relkin N, Small GW, Miller B, Stevens JC. Practice parameter: diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2001; 56:1143–1153.

    Article  CAS  PubMed  Google Scholar 

  14. Anthony J, LeResche L, Niaz U, von Korff M, Folstein M. Limits of the ‘Mini Mental State’ as a screening test for dementia and delirium among hospital patients. Psychol Med 1982; 12:397–408.

    Article  CAS  PubMed  Google Scholar 

  15. Perani D, Di Piero V, Vallar G, Cappa S, Messa C, Bottini G, Berti A, Passafiume D, Scarlato G, Gerundini P. Technetium- 99m HM-PAO-SPECT study of regional cerebral perfusion in early Alzheimer’s disease. J Nucl Med 1988; 29:1507–1514.

    CAS  PubMed  Google Scholar 

  16. Messa C, Perani D, Lucignani G, Zenorini A, Zito F, Rizzo G, Grassi F, Del Sole A, Franceschi M, Gilardi MC. High-resolution technetium-99m-HMPAO SPECT in patients with probable Alzheimer’s disease: comparison with fluorine-18-FDG PET. J Nucl Med 1994; 35:210–216.

    CAS  PubMed  Google Scholar 

  17. Van Gool WA, Walstra GJ, Teunisse S, Van der Zant FM, Weinstein HC, van Royen EA. Diagnosing Alzheimer’s disease in elderly, mildly demented patients: the impact of routine single photon emission computed tomography. J Neurol 1995; 242:401–405.

    Article  CAS  PubMed  Google Scholar 

  18. McMurdo ME, Grant DJ, Kennedy NS, Gilchrist J, Findlay D, McLennan JM. The value of HMPAO SPECT scanning in the diagnosis of early Alzheimer’s disease in patients attending a memory clinic. Nucl Med Commun 1994; 15:405–409.

    Article  CAS  PubMed  Google Scholar 

  19. Claus JJ, van Harskamp F, Breteler MM, Krenning EP, de Koning I, van der Cammen TJ, Hofman A, Hasan D. The diagnostic value of SPECT with Tc 99m HMPAO in Alzheimer’s disease: a population-based study. Neurology 1994; 44:454–461.

    Article  CAS  PubMed  Google Scholar 

  20. Minoshima S, Foster NL, Kuhl DE. Posterior cingulate cortex in Alzheimer’s disease. Lancet 1994; 344:895.

    Article  CAS  PubMed  Google Scholar 

  21. Minoshima S, Giordani B, Berent S, Frey KA, Foster NL, Kuhl DE. Metabolic reduction in the posterior cingulate cortex in very early Alzheimer’s disease. Ann Neurol 1997; 42: 85–94.

    Article  CAS  PubMed  Google Scholar 

  22. Ishii K, Sasaki M, Yamaji S, Sakamoto S, Kitagaki H, Mori E. Demonstration of decreased posterior cingulate perfusion in mild Alzheimer’s disease by means of H2 15O positron emission tomography. Eur J Nucl Med 1997; 24:670–673.

    CAS  PubMed  Google Scholar 

  23. Ibanez V, Pietrini P, Alexander GE, Furey ML, Teichberg D, Rajapakse JC, Rapoport SI, Schapiro MB, Horwitz B. Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer’s disease. Neurology 1998; 50:1585–1593.

    Article  CAS  PubMed  Google Scholar 

  24. Kogure D, Matsuda H, Ohnishi T, Asada T, Uno M, Kunihiro T, Nakano S, Takasaki M. Longitudinal evaluation of early Alzheimer’s disease using brain perfusion SPECT. J Nucl Med 2000; 41:1155–1162.

    CAS  PubMed  Google Scholar 

  25. Braak H, Braak E. Diagnostic criteria for neuropathologic assessment of Alzheimer’s disease. Neurobiol Aging 1997; 18:S85–S88.

    Article  Google Scholar 

  26. Jack CR Jr, Petersen RC, Xu YC, Waring SC, O’Brien PC, Tangalos EG, Smith GE, Ivnik RJ, Kokmen E. Medial temporal atrophy on MRI in normal aging and very mild Alzheimer’s disease. Neurology 1997; 49:786–794. 977

    Article  PubMed Central  PubMed  Google Scholar 

  27. Bobinski M, de Leon MJ, Convit A, De Santi S, Wegiel J, Tarshish CY, Saint Louis LA, Wisniewski HM. MRI of entorhinal cortex in mild Alzheimer’s disease. Lancet 1999; 353: 38–40.

    Article  CAS  PubMed  Google Scholar 

  28. Hodges JR, Patterson K. Is semantic memory consistently impaired early in the course of Alzheimer’s disease? Neuroanatomical and diagnostic implications. Neuropsychologia 1995; 33:441–459.

    Article  CAS  PubMed  Google Scholar 

  29. Kohler S, Black SE, Sinden M, Szekely C, Kidron D, Parker JL, Foster JK, Moscovitch M, Winocour G, Szalai JP, Bronskill MJ, Wincour G. Memory impairments associated with hippocampal versus parahippocampal-gyrus atrophy: an MR volumetry study in Alzheimer’s disease. Neuropsychologia 1998; 36:901–914.

    Article  CAS  PubMed  Google Scholar 

  30. Convit A, de Leon MJ, Tarshish C, De Santi S, Tsui W, Rusinek H, George A. Specific hippocampal volume reductions in individuals at risk for Alzheimer’s disease. Neurobiol Aging 1997; 18:131–138.

    Article  CAS  PubMed  Google Scholar 

  31. Cabeza R, Nyberg L. Imaging cognition II: an empirical review of 275 PET and fMRI studies. J Cogn Neurosci 2000; 12:1–47.

    Article  CAS  PubMed  Google Scholar 

  32. Haxby JV, Grady CL, Koss E, Horwitz B, Heston L, Schapiro M, Friedland RP, Rapoport SI. Longitudinal study of cerebral metabolic asymmetries and associated neuropsychological patterns in early dementia of the Alzheimer type. Arch Neurol 1990; 47:753–760.

    Article  CAS  PubMed  Google Scholar 

  33. Morris JC, Storandt M, McKeel DW Jr, Rubin EH, Price JL, Grant EA, Berg L. Cerebral amyloid deposition and diffuse plaques in “normal” aging: evidence for presymptomatic and very mild Alzheimer’s disease. Neurology 1996; 46:707–719.

    Article  CAS  PubMed  Google Scholar 

  34. Desgranges B, Baron JC, de la Sayette V, Petit-Taboue MC, Benali K, Landeau B, Lechevalier B, Eustache F. The neural substrates of memory systems impairment in Alzheimer’s disease. A PET study of resting brain glucose utilization. Brain 1998; 121:611–631.

    Article  PubMed  Google Scholar 

  35. Cagnin A, Brooks DJ, Kennedy AM, Gunn RN, Myers R, Turkheimer FE, Jones T, Banati RB. In-vivo measurement of activated microglia in dementia. Lancet 2001; 358:461–467.

    Article  CAS  PubMed  Google Scholar 

  36. Jobst KA, Smith AD, Barker CS, Wear A, King EM, Smith A, Anslow PA, Molyneux AJ, Shepstone BJ, Soper N. Association of atrophy of the medial temporal lobe with reduced blood flow in the posterior parietotemporal cortex in patients with a clinical and pathological diagnosis of Alzheimer’s disease. J Neurol Neurosurg Psychiatry 1992; 55:190–194.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  37. Talbot PR, Lloyd JJ, Snowden JS, Neary D, Testa HJ. A clinical role for 99mTc-HMPAO SPECT in the investigation of dementia? J Neurol Neurosurg Psychiatry 1998; 64:306–313.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  38. Signorini M, Paulesu E, Friston K, Perani D, Colleluori A, Lucignani G, Grassi F, Bettinardi V, Frackowiak RS, Fazio F. Rapid assessment of regional cerebral metabolic abnormalities in single subjects with quantitative and nonquantitative [18F]FDG PET: A clinical validation of statistical parametric mapping. Neuroimage 1999; 9:63–80.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Nuclear Medicine, Polikliniek 7, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium

    Ingeborg Goethals, Christophe Van De Wiele & Rudi Dierckx

  2. Division of Nuclear Medicine, Geneva University Hospital, Geneva, Switzerland

    Daniel Slosman

Authors
  1. Ingeborg Goethals
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  2. Christophe Van De Wiele
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  3. Daniel Slosman
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  4. Rudi Dierckx
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Goethals, I., Van De Wiele, C., Slosman, D. et al. Brain SPET perfusion in early Alzheimer’s disease: where to look?. Eur J Nucl Med 29, 975–978 (2002). https://doi.org/10.1007/s00259-002-0872-8

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