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Accuracy of diffusion-weighted MR imaging in the diagnosis of sporadic Creutzfeldt-Jakob disease

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Abstract.

The definitive diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) is based on brain autopsy. The 14-3-3 analysis in the CSF is considered a highly sensitive and specific procedure. Sensitivity, specificity and accuracy of EEG, the 14-3-3 assay and MR imaging in 12 patients referred for suspected sCJD were calculated. We suggest that diffusion-weighted MR imaging (DWI) should be included in the array of diagnostic tests because of the 100 % sensitivity and specificity.

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Authors and Affiliations

  1. Department of Neurology, University Hospital, 3000 Leuven, Belgium, , , , , , BE

    Raf Sciot, Wim Robberecht & René Dom

  2. Department of Medical Imaging Computing, University Hospital, 3000 Leuven, Belgium, , , , , , BE

    Dirk Vandermeulen & Frederik Maes

  3. Department of Radiology, University Hospital, Herestraat 49, 3000 Leuven, Belgium. Philippe.Demaerel@uz.kuleuven.ac.be, , , , , , BE

    Philippe Demaerel & Guido Wilms

Authors
  1. Philippe Demaerel
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  2. Raf Sciot
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  3. Wim Robberecht
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  4. René Dom
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  5. Dirk Vandermeulen
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  6. Frederik Maes
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  7. Guido Wilms
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Additional information

Received: 26 July 2002, Received in revised form: 24 September 2002, Accepted: 9 October 2002

Frederik Maes is a postdoctoral fellow of the Fund for Scientific Research-Flanders (F. W. O.-Vlaanderen, Belgium).

This work was supported by the EC-funded BIOMED-2 program under Grant BMH4-CT98–6048 (Quantitative Analysis of Magnetic Resonance in Creutzfeldt-Jakob disease).

Presented at the 40th Annual Meeting of the American Society of Neuroradiology, Vancouver, May 2002.

Correspondence to Philippe Demaerel, MD, PhD

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Demaerel, P., Sciot, R., Robberecht, W. et al. Accuracy of diffusion-weighted MR imaging in the diagnosis of sporadic Creutzfeldt-Jakob disease. J Neurol 250, 222–225 (2003). https://doi.org/10.1007/s00415-003-0983-6

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  • DOI: https://doi.org/10.1007/s00415-003-0983-6

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