Abstract
Orthostatic hypotension (OH) is a frequent nonmotor feature of Parkinson’s disease (PD), and its occurrence has been associated with cognitive impairment. The underlying mechanism could be mediated by development of cerebrovascular disease induced by chronic or episodic hypoperfusion, but the extent of brain vascular load in PD patients with OH has never been investigated. This study aimed to assess the relationship between OH and cognitive function in PD patients and to investigate the contribution of brain vascular lesions. Forty-eight PD patients underwent a tilt table test (TT) to assess supine and orthostatic blood pressure as well as an extensive neuropsychological evaluation to evaluate cognitive function. Brain magnetic resonance imaging was acquired in 44/48 patients and analyzed by a visual semiquantitative scale. Twenty-three patients presented OH at TT (13/23 were symptomatic), and 25 did not. There were no differences in motor severity or disease duration between patients with and without OH. In patients with OH we found significantly worse cognitive performance in specific tasks, such as sustained attention, visuospatial and verbal memory, compared with patients without OH. However, there were no differences in vascular burden between the two groups. Our study confirms that there is an association between OH and selective cognitive deficits in PD, but rebuts the hypothesis that this is underlined by the development of cerebrovascular disease.
Similar content being viewed by others
References
Ha AD, Brown CH, York MK, Jankovic J (2011) The prevalence of symptomatic orthostatic hypotension in patients with Parkinson’s disease and atypical Parkinsonism. Parkinsonism Rel Disord 17:625–628
Senard JM, Rai S, Lapeyre-Mestre M et al (1997) Prevalence of orthostatic hypotension in Parkinson’s disease. J Neurol Neurosurg Psychiatry 63:584–589
Peralta C, Stampfer M, Karner E, Benke T, Poewe W, Wenning GK (2004) Orthostatic hypotension and attention in Lewy body disorders. Mov Disord 19:S331–S332
Poewe W (2007) Dysautonomia and cognitive dysfunction in Parkinson’s disease. Mov Disord 22(Suppl 17):S374–S378
Idiaquez J, Benarroch EE, Rosales H, Milla P, Ríos L (2007) Autonomic and cognitive dysfunction in Parkinson’s disease. Clin Auton Res 17(2):93–98
Allcock LM, Kenny RA, Mosimann UP, Tordoff S, Wesnes KA, Hildreth AJ, Burn DJ (2006) Orthostatic hypotension in Parkinson’s disease: association with cognitive decline? Int J Geriatr Psychiatry 21:778–783
Hohler AD, Zuzuárregui JR, Katz DI, Depiero TJ, Hehl CL, Leonard A, Allen V, Dentino J, Gardner M, Phenix H, Saint-Hilaire M, Ellis T (2011) Differences in motor and cognitive function in patients with Parkinson’s disease with and without orthostatic hypotension. Int J Neurosci. [Epub ahead of print]
Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55(3):181–184
Tomlinson CL, Stowe R, Patel S, Rick C, Gray R, Clarke CE (2010) Systematic review of levodopa dose equivalency reporting in Parkinson’s disease. Mov Disord 25(15):2649–2653
Antonini A, Abbruzzese G, Ferini-Strambi L, Tilley B, Huang J, Stebbins GT, Goetz CG, Barone P; MDS-UPDRS Italian Validation Study Group (2012) Validation of the Italian version of the movement disorder society-unified Parkinson’s disease rating scale. Neurol Sci. [Epub ahead of print]
The Consensus Committee of the American Autonomic Society and the American Academy of Neurology (1996) Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy. Neurology 46(5):147
Chaudhuri KR, Martinez-Martin P, Brown RG, Sethi K, Stocchi F, Odin P, Ondo W et al (2007) The metric properties of a novel non-motor symptoms scale for Parkinson’s disease: results from an international pilot study. Mov Disord 22:1901–1911
Biundo R, Formento-Dojot P, Facchini S, Vallelunga A, Ghezzo L, Foscolo L, Meneghello F, Antonini A (2011) Brain volume changes in Parkinson’s disease and their relationship with cognitive and behavioural abnormalities. J Neurol Sci 310(1–2):64–69
Scheltens P, Barkhof F, Leys D, Pruvo JP, Nauta JJ, Vermersch P, Steinling M, Valk J (1993) A semiquantative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging. J Neurol Sci 114(1):7–12
Santangelo G, Viatle C, Trojano L, De Gaspari D, Bilo L, Antonini A, Barone P (2010) Differential neuropsychological profiles in Parkinsonian patients with or without vascular lesions. Mov Disord 25(1):50–56
Jordan J, Biaggioni I (2002) Diagnosis and treatment of supine hypertension in autonomic failure patients with orthostatic hypotension. J Clin Hypertens 4(2):139–145
Allcock LM, Kenny RA, Burn DJ (2006) Clinical phenotype of subjects with Parkinson’s disease and orthostatic hypotension: autonomic symptom and demographic comparison. Mov Disord 21(11):1851–1855
Wenning GK, Scherfler C, Granata R et al (1999) Time course of symptomatic orthostatic hypotension and urinary incontinence in patients with postmortem confirmed parkinsonian syndromes: a clinicopathological study. J Neurol Neurosurg Psychiatry 67:620–623
Rose KM, Couper D, Eigenbrodt ML, Mosley TH, Sharrett AR, Gottesman RF (2010) Orthostatic hypotension and cognitive function: the Atherosclerosis risk in Communities study. Neuroepidemiology 34(1):1–7
Duschek S, Matthias E, Schandry R (2005) Essential hypotension is accompanied by deficits in attention and working memory. Behav Med 30:149–158
Weisz N, Schandry R, Jacobs A, Mialet J, Duschek S (2002) Early contingent negative variation of the EEG and attentional flexibility are reduced in hypotension. Int J Psychophysiol 45:253–260
Mehrabian S, Duron E, Labouree F, Rollot F, Bune A, Traykov L, Hanon O (2010) Relationship between orthostatic hypotension and cognitive impairment in the elderly. J Neurol Sci 299:45–48
Viramo P, Luukinen H, Koski K, Laippala P, Sulkava R, Kivela SL (1999) Orthostatic hypotension and cognitive decline in older people. J Am Geriatr Soc 47:600–604
Heims H, Critchley H, Martin N, Jager R, Mathias CJ, Copolotti L (2006) Cognitive functioning in orthostatic hypotension due to pure autonomic failure. Clin Auton Res 16:113–120
Elmstahl S, Rosen I (1997) Postural hypotension and EEG variables predict cognitive decline: results from a 5-year follow-up of healthy elderly women. Dement Geriatr Cogn Disord 8:180–187
Freitag MH, Peila R, Masaki K, Petrovitch H, Ross GW, White LR, Launer LJ (2006) Midlife pulse pressure and incidence of dementia: the Honolulu-Asia Aging Study. Stroke 37:33–37
Van Dijk EJ, Breteler MM, Schmidt R, Berger K, Nilsson LG, Oudkerk M, Pajak A, Sans S, de Ridder M, Dufouil C, Fuhrer R, Giampaoli S, Launer LJ, Hofman A (2004) The association between blood pressure, hypertension, and cerebral white matter lesions: cardiovascular determinants of dementia study. Hypertension 44:625–630
Vokatch N, Grötzsch H, Mermillod B, Burkhard PR, Sztajzel R (2007) Is cerebral autoregulation impaired in Parkinson’s disease? A transcranial Doppler study. Neurol Sci 254(1–2):49–53
Tsai SJ, Chen SC, Leu TM, Chen CM, Chou HH, Peng HY, Liao JM, Lin TB (2009) Impairment of cerebral hemodynamic response to the cold pressor test in patients with Parkinson’s disease. Parkinsonism Relat Disord 15(2):94–100 Epub 2008 Apr 28
Bohnen NI, Albin RL (2011) White matter lesions in Parkinson disease. Nat Rev Neurol 7(4):229–236
Antonini A, Vitale C, Barone P, Cilia R, Righini A, Bonuccelli U, Abbruzzese G, Ramat S, Petrone A, Quatrale R, Marconi R, Ceravolo R, Stefani A, Lopiano L, Zappia M, Capus L, Morgante L, Tamma F, Tinazzi M, Colosimo C, Guerra UP (2012) The relationship between cerebral vascular disease and parkinsonism: The VADO study. Parkinsonism Relat Disord. [Epub ahead of print]
Miklossy J (2003) Cerebral hypoperfusion induces cortical watershed microinfarcts which may further aggravate cognitive decline in Alzheimer’s disease. Neurol Res 25:605–610
Fernández-Seara MA, Mengual E, Vidorreta M, Aznárez-Sanado M, Loayza FR, Villagra F, Irigoyen J, Pastor MA (2012) Cortical hypoperfusion in Parkinson’s disease assessed using arterial spin labeled perfusion MRI. Neuroimage 59(3):2743–2750
Borghammer P, Chakravarty M, Jonsdottir KY, Sato N, Matsuda H, Ito K, Arahata Y, Kato T, Gjedde A (2010) Cortical hypometabolism and hypoperfusion in Parkinson’s disease is extensive: probably even at early disease stages. Brain Struct Funct 214(4):303–317
Nobili F, Abruzzese G, Morbelli S, Marchese R, Girtler N, Dessi B et al (2009) Amnestic mild cognitive impairment in Parkinson’s disease: a brain perfusion SPECT study. Mov Disord 24:414–421
Aliev G, Smith MA, de la Torre JC, Perry G (2004) Mitochondria as a primary target for vascular hypoperfusion and oxidative stress in Alzheimer’s disease. Mitochondrion 4(5–6):649–663
Hai J, Lin Q, Su SH, Zhang L, Wan JF, Lu Y (2011) Chronic cerebral hypoperfusion in rats causes proteasome dysfunction and aggregation of ubiquitinated proteins. Brain Res 1374:73–81
Conflicts of interest
All authors have no financial or other conflicts of interest that might bias their work.
Ethical standard
This study has been approved by local ethic committee of IRCCS San Camillo and has been performed in agreement with the ethical standards laid down in the 1964 declaration of Helsinki.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Pilleri, M., Facchini, S., Gasparoli, E. et al. Cognitive and MRI correlates of orthostatic hypotension in Parkinson’s disease. J Neurol 260, 253–259 (2013). https://doi.org/10.1007/s00415-012-6627-y
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00415-012-6627-y