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Paraoxonase polymorphisms, pesticide exposure and Parkinson's disease in a Caucasian population

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Summary.

Parkinson's disease (PD) has been associated with exposure to pesticides and oxidative injury. The involvement of paraoxonase in both pesticide metabolism and lipid peroxidation suggests that it may play a role in the pathogenesis of PD. We examined the frequency of polymorphic alleles of the PON1 and PON2 genes in a sample of caucasian subjects with PD. The frequency distribution of these genotypes did not differ significantly between patients and controls, including those who had reported exposure to pesticides.

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Authors and Affiliations

  1. Molecular Genetics Group, John Curtin School of Medical Research, Acton,, , , , ,

    M. C. Taylor, D. G. Le Couteur & P. G. Board

  2. Department of Medicine, University of Queensland, Brisbane, Australia, , , , , , AU

    G. D. Mellick

Authors
  1. M. C. Taylor
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  2. D. G. Le Couteur
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  3. G. D. Mellick
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  4. P. G. Board
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Received August 20, 1999; accepted January 18, 2000

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Taylor, M., Le Couteur, D., Mellick, G. et al. Paraoxonase polymorphisms, pesticide exposure and Parkinson's disease in a Caucasian population. J Neural Transm 107, 979–983 (2000). https://doi.org/10.1007/s007020070046

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  • DOI: https://doi.org/10.1007/s007020070046

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