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Bilateral Complete Optic Atrophy and Hemorrhagic Infarction of the Putamen Caused by Methanol Intoxication

  • Case Report
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Annals of Ophthalmology

Abstract

Methanol is a potent toxic substance for the optic nerves. Even small amounts of ingested methanol can acute permanent neurological dysfunction and irreversible blindness. Methanol intoxication can cause severe visual dysfunction and death. We present a case of a 25 years old admitted to our clinic with bilateral optical atrophy after drinking eau de cologne.

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References

  1. Younger DS. Pollutants and industrial hazards. In: Rowland LP, ed. Merritt’s Textbook of Neurology, 9th ed. Baltimore: Williams and Wilkins,1995, pp. 992–993

    Google Scholar 

  2. Prabhakaran V, Ettler H, Mills A. Methanol poisoning: two cases with similar plasma methanol concentrations but different outcomes. Can Med Assoc J 1993;148:981–984

    CAS  Google Scholar 

  3. Onder F, Ilker S, Kansu T, et al. Acute blindness and putaminal necrosis in methanol intoxication. Int Ophthalmol 1998–1999;22:81–84

    Google Scholar 

  4. Cursiefen C, Bergua A. Acute bilateral blindness caused by accidental methanol intoxication during fire “eating”. Br J Ophthalmol 2002;86:1064–1065

    Article  PubMed  CAS  Google Scholar 

  5. Kruse JA. Methanol poisoning. Intensive Care Med 1992;18:391–397

    Article  PubMed  CAS  Google Scholar 

  6. Gonda A, Gault H, Churchill D, et al. Hemodialysis for methanol intoxication. Am J Med 1978;64:749–758

    Article  PubMed  CAS  Google Scholar 

  7. Liesivuori J, Savolainen H. Methanol and formic acid toxicity: Biochemical mechanisms. Pharmacol Toxicol 1991;69:157–163

    Article  PubMed  CAS  Google Scholar 

  8. McMartin KE, Ambre JJ, Tephly TR. Methanol poisoning in human subjects. Role for formic acid acumulation in the metabolic acidosis. Am J Med 1980;68:414–418

    Article  PubMed  CAS  Google Scholar 

  9. Potts AM, Johnson LV. Studies on the visual toxicity of methanol. The effect of methanol and its degradation products on retinal metabolism. Am J Ophthalmol 1952;35:107–113

    PubMed  CAS  Google Scholar 

  10. Jacobsen D, McMartin KE. Methanol and ethylene glycol poisonings. Mechanism of toxicity, clinical course, diagnosis and treatment. Med Toxicol 1986;1:309–334

    PubMed  CAS  Google Scholar 

  11. Sharma M, Volpe NJ, Dreyer EB. Methanol-induced optic nerve cupping. Arch Ophthalmol 1999;117:286

    PubMed  CAS  Google Scholar 

  12. McKellar MJ, Hidajat RR, Elder MJ. Acute ocular methanol toxicity: clinical and electrophysiological features. Aust NZ J Ophthalmol 1997;25:225–230

    CAS  Google Scholar 

  13. Benton CD, Calhoun FP. The ocular effects of methyl alcohol poisoning: Report of a catastrophe involving three hundred and twenty persons. Trans Am Acad Ophthalmol 1952;56:875–883

    Google Scholar 

  14. Agency for toxic substances and disease Registry. Methanol toxicity. Am Fam Physician 1993;47:163–171

    Google Scholar 

  15. Jacobsen D, McMartin KE. Antidotes for methanol and ethylene glycol poisoning. Clin Toxicol 1997;35:127–143

    CAS  Google Scholar 

  16. Palmisano I, Gruver C, Adams ND. Absence of anion gap metabolic acidosis in severe methanol poisoning: A case report and review of the literature. Am J Kidney Dis 1987;9:441–444

    PubMed  CAS  Google Scholar 

  17. Chow MT, Di Silvestro VA, Yung CY, et al. Treatment of acute methanol intoxication with hemodialysis using an ethanol-enriched, bicarbonate-based dialysate. Am J Kidney Dis 1997;30:568–570

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, Diyarbakır State Hospital, Diyarbakır Devlet Hastanesi, Diyarbakir, 21280, Turkey

    Şeyhmus Ari MD

  2. Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakir, Turkey

    İhsan Çaça MD

  3. Department of Internal Medicine, Dicle University Faculty of Medicine, Diyarbakir, Turkey

    Hasan Kayabaşi MD

Authors
  1. Şeyhmus Ari MD
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  2. İhsan Çaça MD
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  3. Hasan Kayabaşi MD
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Corresponding author

Correspondence to Şeyhmus Ari MD.

Additional information

Dr. Ari is from the Department of Ophthalmology, Diyarbakır State Hospital, Diyarbakır, Turkey. Dr. Çaça is an Associate Professor in the Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakır, Turkey. Dr. Kayabaşi is from the Department of Internal Medicine, Dicle University Faculty of Medicine, Diyarbakır, Turkey.

The authors have stated that they do not have a significant financial interest or other relationship with any product manufacturer or provider of services discussed in this article. The authors do not discuss the use of off-label products, which includes unlabeled, unapproved, or investigative products or devices.

The authors present a case of a 25-year-old admitted to our clinic with bilateral optical atrophy after drinking eau de cologne.

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Ari, Ş., Çaça, İ. & Kayabaşi, H. Bilateral Complete Optic Atrophy and Hemorrhagic Infarction of the Putamen Caused by Methanol Intoxication. Ann Ophthalmol 39, 249–252 (2007). https://doi.org/10.1007/s12009-007-0038-1

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  • DOI: https://doi.org/10.1007/s12009-007-0038-1

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