Clinical study
Metastatic thyroid carcinoma provoking hyperthyroidism, with elevated circulating thyrostimulators

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Abstract

The clinical and laboratory findings in three cases of metastasizing thyroid carcinoma are reported. In all instances the clinical signs of hyperthyroidism were observed in the absence of a normal functioning thyroid gland. Blood hormonal iodine levels, composed mainly of thyroxine, were elevated. Besides butanol-extractible iodine, large quantities of butanol-insoluble radioiodine were found in the blood of these three patients after 131I therapy. The butanol-insoluble radioiodine consisted of thyroglobulin, albumin-like iodoprotein and beta-gamma globulin-like iodoprotein. Despite increased blood levels of thyroxine, both free and bound to serum proteins, and the presence of long-acting thyroid stimulator in the blood of the three patients, thyroid-stimulating hormone in the plasma was also increased. Impairment of the feed-back thyroid pituitary mechanism is suggested.

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  • Cited by (0)

    1

    From the Research Institute of Endocrinology, Prague, Czechoslovakia.

    2

    From the Clinique Medicale Universitaire, Lausanne, Switzerland.

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