Loss of social group affinity following prefrontal lesions in free-ranging macaques
Reference (29)
- et al.
Differential effects of cortical lesions in infant and adult cats in roughness discrimination
Exp. Neurol.
(1959) - et al.
Neural control of social behavior: Prefrontal and anterior temporal cortex
Neuropsychologia
(1973) - et al.
Age effects on social behavior deficits following prefrontal lesions in monkeys
Brain Research
(1973) - et al.
Social behavior deficits of free-ranging monkeys after anterior temporal cortex removal: a preliminary report
Brain Research
(1970) Comparative anatomy of frontal cortex and thalamo-frontal connections
- et al.
Anterior temporal cortex and maternal behavior in monkey
Neurology (Minneap.)
(1970) Sexual behavior of free-ranging rhesus monkeys (Macaca mulatta); specimens, procedures, and behavioral characteristics of estrus
J. comp. Psychol.
(1942)The conditioned inhibition of uncinate fits
Brain
(1957)- et al.
The effects of bilateral prefrontal lesions on learned behavior of neonatal, infant and preadolescent monkeys
Mental symptoms associated with tumors of the frontal lobe
Cingulate, posterior orbital, anterior insular and temporal pole cortex
Reorganization of motor function in cerebral cortex of monkeys deprived of motor and premotor areas in infancy
J. Neurophysiol.
Alterations in response to visual stimuli following lesions of frontal lobes in monkeys
Arch. Neurol. Psychiat. (Chic.)
Population dynamics of rhesus monkeys on Cayo Santiago
Cited by (79)
The social dilemma: prefrontal control of mammalian sociability
2021, Current Opinion in NeurobiologyCitation Excerpt :Prefrontal damage was also associated with deficits in theory of mind [38], impairment in the ability to express social emotions such as empathy [39] and conform to cultural moral norms [40], and difficulties in interpreting the emotions of others [38,41]. A corresponding reduction in prosocial behaviors was reported in lesion studies in primates [42] and rodents alike [43]. Reduced glucose metabolism was identified in the mPFC of adopted Romanian orphans who reportedly displayed social deficits after suffering from severe social deprivation during early childhood [44].
The cingulum bundle: Anatomy, function, and dysfunction
2018, Neuroscience and Biobehavioral ReviewsExtinction of fear is facilitated by social presence: Synergism with prefrontal oxytocin
2016, PsychoneuroendocrinologyCitation Excerpt :The Pavlovian contextual conditioning paradigm was previously shown to be dependent on the mPFC (Kritman and Maroun, 2012; Laurent and Westbrook, 2008). Meta-analysis of imaging studies has shown that the mPFC is especially sensitive to experiments involving both social and emotional tasks (Gilbert et al., 2006). Furthermore, it has been shown that prefrontal lesions cause deficits in social behavior, such as loss of social group affinity in monkeys (Myers et al., 1973) or disclosure to strangers in an inappropriately intimate fashion in humans (Beer et al., 2003). The mPFC is also implicated in extinction of fear, as manipulations of the IL-mPFC result in impairments in fear extinction, mainly in the recall of extinction memory (Milad and Quirk, 2002).
Neuroanatomical and neurochemical basis of parenting: Dynamic coordination of motivational, affective and cognitive processes
2016, Hormones and BehaviorCitation Excerpt :These heightened cognitive skills are likely due to structural and functional changes in prefrontal cortical regions, including the OFC, dlPFC, dACC/dmPFC, parietal cortex, along with subcortical regions, such as the septum, thalamus and striatum, specifically the caudate and nucleus accumbens, as well as altered DA activity (Hamilton et al., 1977; Kim et al., 2010; Kinsley and Lambert, 2008; Leuner and Gould, 2010; Oatridge et al., 2002; Pawluski and Galea, 2007; Sabihi et al., 2014; Salmaso and Woodside, 2008). Permanent lesions and transient inactivation of many of these regions severely impair maternal behavior in primates and rodents (Afonso et al., 2007; Franzen and Myers, 1973; Murphy et al., 1981; Myers et al., 1973; Pereira and Morrell, 2011; Slotnick, 1967; Slotnick and Nigrosh, 1975; Stamm, 1955). For instance, interference with dorsal mPFC or ACC activity affects the organizational aspects of rat maternal behavior during both early and late postpartum periods, likely by inducing deficits in attention and behavioral inhibition processes, although mother rats remain very interested in pups (Afonso et al., 2007; Pereira and Morrell, 2011; Slotnick, 1967; Slotnick and Nigrosh, 1975; Stamm, 1955).
Parenting Behavior
2015, Knobil and Neill's Physiology of Reproduction: Two-Volume SetTheory of Mind in normal ageing and neurodegenerative pathologies
2012, Ageing Research ReviewsCitation Excerpt :Lesion studies may provide some information on the neural mechanisms implicated in social behavior. The results of most works on nonhuman primates support the general conclusion that the orbitofrontal (OF) cortex plays a critical role in species-typical social behavior (Deets et al., 1970; Franzen and Myers, 1973; Machado and Bachevalier, 2006; Myers et al., 1973). For example, studies in rhesus macaques allowed to freely interact with partner animals showed that lesioned animals (i.e., those with damage to the OF cortex) differed from control macaques in terms of social interest and fear-related behaviors (Babineau et al., 2011).
- *
Present address: Harvard Medical School, Department of Psychiatry, Boston, Mass. 02115, U.S.A.
- **
Present address: Rutgers Medical School, Department of Psychiatry, New Brunswick, N.J. 08903, U.S.A.