Elsevier

Brain Research

Volume 178, Issues 2–3, 14 December 1979, Pages 567-572
Brain Research

Inputs to the swallowing medullary neurons from the peripheral afferent fibers and the swallowing cortical area

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Cited by (117)

  • Cerebral control of swallowing: An update on neurobehavioral evidence

    2022, Journal of the Neurological Sciences
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    While the brainstem is often regarded as the most important structure for swallowing, studies have also identified the vital role of the cerebral cortex in mediating swallowing (Table 1). Early studies with anaesthetized sheep found that swallowing can be evoked by repeated stimulation of the orbitofrontal cortex [10]. Activation of “early” NTS neurons, which fire before or during the oropharyngeal stage of swallowing, following cortical stimulation suggested that this region might be responsible for triggering of swallowing in sheep.

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  • Laryngeal Closure during Swallowing in Stroke Survivors with Cortical or Subcortical Lesion

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    The results of this investigation imply that the subcortex is more involved in responding to the ILC during the pharyngeal swallow. Damage in the sensorimotor pathway between the cortex and brainstem, which passes through the basal ganglia, may interrupt the ILC in stroke survivors with subcortical lesion.19,24,25 The findings in this investigation support the idea that laryngeal closure can be initiated and supported through sensorimotor pathways associated with the subcortex.26

  • Role of the dorsal medulla in the neurogenesis of airway protection

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    Jean and co-workers [27,31,32] concluded that the dorsal swallow group had a sensory processing function because short latency neuronal responses to electrical stimulation of the superior laryngeal nerve were frequently observed in the NTS region relative to longer latency responses of neurons to this stimulus that were seen in the ventrolateral medulla. However, microinjection of NMDA and glutamate into the NTS induces rhythmic swallowing [28,33] and lesion of this area eliminates swallowing induced by electrical stimulation of supra-pontine structures [34], which supports a role for this medullary region in rhythmogenesis of this behavior. The roles of other brainstem regions known to contain swallow-responsive neurons and/or receive anatomical projections from the DSG/VSG, such as the pons and rostromedial reticular formation, are not fully understood [27].

  • The generation of pharyngeal phase of swallow and its coordination with breathing: Interaction between the swallow and respiratory central pattern generators

    2014, Progress in Brain Research
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    The pharyngeal phase produced by direct stimulation of the NTS is relatively unmodified by paralysis by curarization or by sensory deafferentation (Doty and Bosma, 1956; Kessler and Jean, 1985). Furthermore, electrolytic and chemical lesion of the NTS completely abolishes swallows produced by either cortical or SLN sensory afferent stimulation (Jean and Car, 1979; Wang and Bieger, 1991). The cellular mechanisms present in the NTS that transform the swallow-related sensory information into the vigorous bursting relayed to upper airway and alimentary motoneurons are outside the scope of this review and have been previously discussed at length in the seminal review by Jean (2001).

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This work was supported partly by grants from CNRS (LA 205) and INRA.

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We are indebted to Prof. C. Roman for his valuable assistance in the preparation of the manuscript. We thank D. Catalin for his technical help.

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