Elsevier

Brain Research

Volume 598, Issues 1–2, 11 December 1992, Pages 154-161
Brain Research

Individual differences in brain asymmetries and fiber composition in the human corpus callosum

https://doi.org/10.1016/0006-8993(92)90179-DGet rights and content

Abstract

There have been several recent reports concerning individual differences inthe gross morphometry of the human corpus callosum. However, no studies exist on individual differences in the fiber composition of the corpus callosum. Here we report for the first time the relation of fiber composition in specific callosal segments (as seen in light microscopy) to anatomical asymmetries in language-gifted cortex, as a function of sex. We found a significant negative correlation between Sylvian fissure asymmetries and the total numbers of fibers in the isthmus of males, and in the anterior splenium of females. In addition, a population of relatively large fibers (between 1 μm and 3 μm in diameter) in the isthmus showed a strong negative correlation with perisylvian asymmetries only in males. These findings suggest a sex-dependent, pathway-specific decrease in interhemispheric connectivity with increasing lateralization.

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