Lymphocyte migration into brain modelled in vitro: Control by lymphocyte activation, cytokines, and antigen☆
References (21)
- et al.
Science
(1983) - et al.
J. Immunol
(1986) - et al.
Immunology
(1988) - et al.
Immunology
(1986) - et al.
J. Immunol
(1986) - et al.
Annu. Rev. Immunol
(1987) - et al.
J. Immunol
(1984) - et al.
J. Immunol
(1986) - et al.
J. Immunol
(1986) - et al.
Neurosci. Lett
(1986)
Cited by (111)
Hypothalamitis and pituitary atrophy
2021, Handbook of Clinical NeurologyCitation Excerpt :Cultured glial, but not neuronal cells are able to express HLA class II molecules that can present antigens in vitro (Fontana et al., 1984). A further immunological protection of the brain is provided by the fact that lymphocytes are much less adhesive for brain microvessel endothelium than extracerebral endothelium, but adhesion can be increased by stimulation of endothelial cells with interferon gamma or tumor necrosis factor-alpha (Male et al., 1990a). Mitogen-activated lymphocytes or T cells activated by their specific antigen bind more effectively than resting lymphocytes (Male et al., 1990b).
Injection of the sciatic nerve with TMEV: A new model for peripheral nerve demyelination
2007, VirologyCitation Excerpt :These results indicated that the adaptive immune response plays a critical role in protection of mice inoculated with TMEV via the sciatic nerve. Inflammatory cells are not detected in normal PNS or CNS (Male et al., 1992; Male et al., 1990a,b; Wekerle et al., 1986) but damage to either the PNS or CNS can culminate in the recruitment of inflammatory and/or immune cells to the site of injury (Male et al., 1990a, 1992). Lymphocytic infiltration of the brain in the TMEV model of CNS demyelination is apparent by 3–5 days p.i. (Lindsay and Rodriguez, 1989; Lindsley et al., 1988); the tissue is infiltrated by T and B cells as well as macrophages (Lindsley et al., 1988).
Amelioration of CR-EAE with lisofylline: Effects on mRNA levels of IL-12 and IFN-γ in the CNS
2000, Journal of NeuroimmunologySerum endothelial adhesion molecules levels correlate with lesion burden in multiple sclerosis patients treated with interferon beta-1b
2000, Neurochemistry InternationalTemporal kinetics and cellular phenotype of TNF p55/p75 receptors in experimental allergic encephalomyelitis
1999, Journal of Neuroimmunology
- ☆
This work was supported by grants from the Medical Research Council of Great Britain and the Wellcome Trust.