Corticospinal projections to upper and lower limb spinal motoneurons in man☆
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2021, Neuroscience LettersCitation Excerpt :Transcranial Magnetic Stimulation: TMS has been widely used to test connectivity in the human corticospinal system, and this is usually done with the subject at rest. These studies have been very useful at determining the pattern of corticospinal influence over different single muscles and muscle groups [79–81], and the pathophysiology of the CM system demonstrable in the early stages of ALS [82–86]. TMS has also been used to demonstrate that M1 outputs can elicit larger Motor Evoked Potentials in a target muscle when it is employed in a complex action than when the muscle is used alone [87,88].
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This research was supported by the Natural Sciences and Engineering Research Council, the Medical Research Council (Grant no. 6727) and the Easter Seal Research Institute.
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We thank Dr. R.D.G. Blair for the use of the evoked potential laboratory's recording equipment.