Research paperDiminished baroreceptor sensitivity in elderly hypertensives Possible role of atherosclerosis
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Cited by (43)
Essential hypertension - Is erroneous receptor output to blame?
2012, Medical HypothesesCitation Excerpt :Erroneous output form baroreceptors could be caused by both mechanical and biochemical factors affecting either an arterial wall or baroreceptor nerve endings. Arteriosclerosis has been found to decrease the sensitivity of baroreceptors and baroreflex in animals [28,29] and humans [30,31]. Stiffer blood vessels are one of the possible explanations for the dysfunction of baroreceptors.
Carotid barochemoreceptor pathological findings regarding carotid plaque status and aging
2009, Canadian Journal of CardiologyAbnormalities of cardiac autonomic nervous activity correlate with expansive coronary artery remodeling
2008, AtherosclerosisCitation Excerpt :Angell-James described a reduced afferent baroreceptor activity in atherosclerotic animals [19]. Vlachakis et al. proposed that atherosclerosis contributes to autonomic dysfunction in elder hypertensive patients [20]. Receptor nerve endings terminate in the vascular adventitia [10].
Effects of ACE Inhibition and β-Blockade on Plasminogen Activator Inhibitor-1 and Transforming Growth Factor-β<inf>1</inf> in Carotid Glomus and Autonomic Ganglia in Hypertensive Rats
2007, American Journal of HypertensionCitation Excerpt :After observing our results in this study, undoubtedly, the emergent question should be what is the clinical importance and projection of these data? A possible answer could be based on the information suggesting that the baroreflex attenuation in humans might be a consequence of atherosclerotic or hypertensive processes.29,30 Furthermore, a fibrotic appearance of the CG has been demonstrated in elderly patients, suggesting an arteriolar involvement leading to fibrosis by a chronic hypoxic mechanism.31
Aspirin restores normal baroreflex function in hypercholesterolemic rats by its antioxidative action
2007, European Journal of PharmacologyArterial baroreflex dysfunction promotes atherosclerosis in rats
2005, Atherosclerosis
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The Joe Lowe and Louis Price Professor of Medicine