ReviewCholine acetyltransferase activity and histopathology of frontal neocortex from biopsies of demented patients☆
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Cited by (188)
Aronia melanocarpa (Michx.) Elliot fruit juice reveals neuroprotective effect and improves cognitive and locomotor functions of aged rats
2019, Food and Chemical ToxicologyCitation Excerpt :Neurotransmission in the cholinergic system is involved in processes, such as learning, memory, sleep, etc. Moreover, cholinergic innervation is directly related to memory consolidation processes (Bowen et al., 1982; Squire et al., 1992) and problems with neurotransmission elicit changes in these functions, which may be one of the causes of senile dementia or Alzheimer disease (Davies, 1983; Orta-Salazar et al., 2014). The selective lesion of cholinergic neurons in the basal forebrain significantly impairs hippocampus-dependent memory function, suggesting a role of septohippocampal cholinergic projections in memory formation (Berger-Sweeney et al., 2001).
Chronic treatment with taurine after intracerebroventricular streptozotocin injection improves cognitive dysfunction in rats by modulating oxidative stress, cholinergic functions and neuroinflammation
2017, Neurochemistry InternationalCitation Excerpt :Apart from cholinesterases, choline acetyltransferase (ChAT) being a rate limiting enzyme in synthesis plays a prominent role in maintenance of ACh level. Bowen et al. (1982) had reported decreased ChAT activity in demented patients. Results of this study revealed that the expression of ChAT was significantly decreased in hippocampus, while insignificant decrease was observed in the cortex of ICV-STZ group.
Nonvascular retinal imaging markers of preclinical Alzheimer's disease
2016, Alzheimer's and Dementia: Diagnosis, Assessment and Disease MonitoringCitation Excerpt :Although we acknowledge that symptomatic AD patients have shown a thinning of the RNFL [19,41], in contrast to our current findings in the preclinical population, we hypothesize that the finding that the cholinergic-rich IPL seems to be the central neuronal layer affected in our population is important and specific to a preclinical AD population. A disruption to the cortical cholinergic system is one of the most reliable and earliest neurochemical changes in AD [50]. Recent imaging studies of the cortical cholinergic system in living AD patients have supported an early cholinergic disruption [51,52].
Co-morbid beta-amyloid toxicity and stroke produce impairments in an ambiguous context task in rats without any impairment in spatial working memory
2015, Neurobiology of Learning and MemoryLongitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to Alzheimer's disease
2013, Neurobiology of AgingCitation Excerpt :Considering the marked BF atrophy rates in healthy elderly observed in the present study, age-related atrophy should be less developed in younger control groups and thus, structural differences attributable to early AD pathology should be more pronounced and easier to detect. Accordingly, postmortem studies found that cholinergic loss in initial stages of the disease is easier to detect in presenile than in senile AD (Bowen et al., 1982; DeKosky et al., 2002; Gilmor et al., 1999) and, likewise, it has been hypothesized that this observation might be explained by age-related cholinergic decline (Mesulam, 2004). Baseline differences in BF and hippocampus volume between healthy control subjects and vmAD resemble the findings of our previous cross-sectional in vivo study on BF degeneration in aging and early AD (Grothe et al., 2012).
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This work was financially supported by the Brain Research Trust, Medical Research Council and Miriam Marks Charitable Trust.
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Present address: The Queen Elizabeth Hospital for Children London, Great Britain.
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Present address: Wessex Neurological Centre, Southampton General Hospital, Great Britain.