Some morphometric observations on the cerebral cortex and hippocampus in presenile Alzheimer's disease, senile dementia of Alzheimer type and Down's syndrome in middle age☆
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Non-tau based neuronal degeneration in Alzheimer's disease - an immunocytochemical and quantitative study in the supragranular layers of the middle temporal neocortex
2008, Brain ResearchCitation Excerpt :In fact, the amount of neuronal loss in the AD neocortex is a matter of controversy. Generally, neurons, particularly those with a size of over 90 µm2, are lost in the temporal and frontal neocortex of AD patients, as compared to those of non-demented controls (Terry et al., 1981; Mountjoy et al., 1983; Mann et al., 1985), while the severity of neuronal loss in AD compared to normal aging tends to decline with the years (Mountjoy et al., 1983; Hubbard and Anderson, 1985; Mann et al., 1985). A correlation between NFT counts and neuronal loss was repeatedly found in the AD neocortex (Mountjoy et al., 1983; Bondareff et al., 1989; Gomez-Isla et al., 1997).
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This work was supported in part by a grant to one of us (B.M.) from the North Western Regional Health Authority.