Event-related potentials in Parkinson's disease: A 12-month follow-up study

doi:10.1016/0022-510X(93)90319-T

Journal of the Neurological Sciences

Volume 116, Issue 2, June 1993, Pages 148-151

https://doi.org/10.1016/0022-510X(93)90319-T Get rights and content

Abstract

Auditory event-related potentials were recorded using the oddball paradigm in 26 patients with Parkinson's disease, all treated with l-Dopa. The latency of the P3 wave was significantly greater than in an age-matched controls, and was also correlated with the disease duration, but not with scores on two scales measuring cognitive deficit. One year later, when treatment with a dopaminergic agonist, bromocriptine 20–30 mg/day, had been added to the therapeutic regimen, N2 and P3 latencies had increased, whereas several clinical parameters had improved. Thus a longer P3 latency does not seem to be linked to a global cognitive deficit. The use of neuropsychological tests exploring more limited tasks should show the prospective utility of event-related potentials in Parkinson's disease.

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Cited by (28)

Event-related potential changes due to early-onset Parkinson's disease in parkin (PARK2) gene mutation carriers and non-carriers
2020, Clinical Neurophysiology
Citation Excerpt :
In the present study, we found prolonged P3b latency, similar to earlier reports on non-demented PD groups (Aotsuka et al., 1996; Elwan et al., 1996; Wright et al., 1996; Tachibana et al., 1997; Wang et al., 1999). However, this finding is not supported by other groups (Stanzione et al., 1991; Toda et al., 1993; Rumbach et al., 1993; Green et al., 1996). We compared an early-onset PD group with healthy controls, and we observed reduced target P3 in both the EOPD-NC and EOPD-PC groups.
To investigate cognitive functions in non-demented patients with early-onset Parkinson's disease (PD), and to compare PARK2 gene mutation carriers and non-carriers by means of event-related brain potentials (ERPs).
The participants comprised patients with early-onset PD (EOPD) and healthy controls (HC). Patients with EOPD were divided into two groups as carriers of known pathogenic variants of PARK2 gene (EOPD-PC) and non-carriers of genes involved in familial PD (EOPD-NC). ERP data were collected during auditory oddball and visual continuous performance test (CPT).
Both EOPD groups (EOPD-PC and EOPD-NC) displayed reduced and delayed P3 in response to oddball target and CPT NoGo. CPT Go P3 was reduced in EOPD-NC but not in EOPD-PC. Oddball target N1 was reduced and P2 was enhanced in both EOPD-PC and EOPD-NC. In both cognitive tasks, RTs were prolonged and accuracy was lower in EOPD-PC and EOPD-NC.
We found several EOPD-related neurophysiologic changes, implying impairments in cognitive functions. Pairwise comparisons between EOPD-PC and EOPD-NC revealed no significant ERP marker.
In this study, the confounding effect of normative aging was somewhat excluded compared with many previous studies. In contrast with the many oddball studies in non-demented PD, we clearly observed reduced and prolonged P3 in early-onset PD. Our NoGo P3 findings also contribute to the limited ERP research concerning response inhibition.
Central auditory processing in parkinsonian disorders: A systematic review
2020, Neuroscience and Biobehavioral Reviews
Citation Excerpt :
Interestingly, performance on the motor section of the UPDRS was significantly better at follow-up compared to the first examination in this study. It should be noted that Rumbach et al. (1993) used a different response mode at the first (motor response) and the follow-up examination (counting), which may have biased the results. In contrast, a positive correlation between N2 peak latency and bradykinesia and rigidity (Ebmeier et al., 1992a), as well as between the motor section of the UPDRS and the P2-N2 peak-to peak amplitude, but only at Pz electrode position (Yilmaz et al., 2017), has been reported.
Altered auditory processing has been increasingly recognized as a non-motor feature in parkinsonian disorders. This systematic review provides an overview of behavioral and electrophysiological literature on central auditory processing in patients with Parkinson’s disease (PD), multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). A systematic database search was conducted and yielded 88 studies that met the intelligibility criteria. The collected data revealed distinct impairments in a range of central auditory processes in PD, including altered deviance detection of basic auditory features, auditory brainstem processing, auditory gating and selective auditory attention. In contrast to PD, literature on central auditory processing in atypical parkinsonian disorders was relatively scarce, but provided some evidence for impaired central auditory processing in MSA and PSP. The interpretation of these findings is discussed and suggestions for further research are offered.
Event-related potentials and cognition in Parkinson's disease: An integrative review
2016, Neuroscience and Biobehavioral Reviews
Cognitive impairment is a common non-motor symptom of Parkinson’s disease (PD), but the nature of cognitive changes varies considerably between individuals. According to the dual-syndrome hypothesis, one cluster of patients is characterized by deficits in executive function that may be related to fronto-striatal dysfunction. Other patients primarily show non-frontal cognitive impairments that progress rapidly to PD dementia (PDD). We provide a comprehensive review of event-related potential (ERP) studies to identify ERP measures substantiating the heterogeneity of cognitive impairment in PD. Our review revealed evidence for P3b and mismatch-negativity alterations in PDD, but not in non-demented PD, indicating that alterations of these ERPs constitute electrophysiological markers for PDD. In contrast, ERP correlates of executive functions, such as NoGo-P3, N2, and error(-related) negativity (N_e/ERN), appear to be attenuated in non-demented PD patients in a dopamine-dependent manner. Hence, ERP measures confirm and yield distinct electrophysiological markers for the heterogeneity of cognitive impairment in PD. We discuss limitations and open questions of the ERP approach and provide directions and predictions for future ERP research.
Auditory event-related potentials in Parkinson's disease: Prominent correlation with attention
2007, Parkinsonism and Related Disorders
Citation Excerpt :
A relationship between P300 prolongation and WCST has been postulated [26,27]. However, some studies have not shown a significant correlation between P300 latency and performance of general cognitive ability [19,28,29]. Recent studies showed a significant correlation between P300 latency and the Raven Colored Progressive Matrices, WCST, and the MMSE [30,31].
Objective: Auditory P300 has been reported to be abnormal in demented patients with Parkinson's disease. However, it is still controversial which factors in Parkinson's disease influence P300 parameters.
Methods: Forty patients with Parkinson's disease were included. Patients were divided into two groups: patients with dementia (PDD) and without dementia (PDND). An ‘odd-ball’ paradigm was used for auditory event-related potentials.
Results: P300 latency was markedly delayed in PDD patients. Age and DRS1 (attention) were the most important factors influencing P300 latency.
Conclusions: Although there have been reports of P300 in the past, its abnormalities reflect the deficit of attention in Parkinson's disease.
Event-related potentials for response inhibition in Parkinson's disease
2005, Neuropsychologia
This study investigated inhibitory function in patients with Parkinson's disease (PD) by recording event-related brain potentials (ERPs) during a Go/NoGo task. Fourteen healthy volunteers and 13 patients with PD without dementia performed a cued continuous performance test that included Go and NoGo trials. The peak latency, amplitude, and topographic distributions of the ERPs to Go and NoGo stimuli were analyzed. Cognitive function was evaluated using the Wisconsin Card Sorting Test (WCST), Kana Pick-out Test, and Verbal Fluency Test (VFT). Performances in the WCST and VFT were significantly impaired in the PD group as compared with the control group. The PD group had significantly higher rates of omission and commission errors during the ERP task. The ERP study found no differences in the latency and amplitude of the Go-P3 between the two groups. By contrast, the NoGo-P3 latency was significantly longer in the PD group than in the control group. The amplitudes of the NoGo-P3 and NoGo-N2 were also significantly smaller in the PD group than in the control group. The NoGo-P3 latency was significantly correlated with the Kana Pick-out Test and VFT scores. The NoGo-P3 amplitude was significantly correlated with the WCST and VFT scores, as well as with the number of commission errors. There were no significant correlations between the cognitive function tests and either the Go-P3 or NoGo-N2 measures. The behavioral and ERP data suggest that there is selective impairment of inhibitory function in PD and that this deficit may be related to impaired inhibitory executive function in the frontal lobe.
Habituation of event-related potentials in patients with Parkinson's disease
2000, Physiology and Behavior
Auditory event-related potential (ERP) was studied in idiopathic Parkinson's disease (PD) using our new procedures. We examined 12 non-demented patients with PD, and 9 age-matched control subjects. Ninety responses induced by rare stimulation were continuously recorded from Fz, Cz, Pz referred to linked earlobe electrode (A1A2), and were divided into nine blocks (one block = 10 responses) for statistical analysis. We assessed the habituation of auditory ERP to detect delicate changes related to the information processing in PD. N100 and P300 latencies were significantly longer in PD than in control subjects (p < 0.05). P300 latency gradually increased with progression of recording blocks in both PD and control subjects, whereas N100 latency increased only in PD. Three way analysis of variance for P300 amplitude revealed significant effects of subject group, recording electrode site, and trial block. P300 amplitude was smaller in PD than in control subjects. Significant negative correlation between P300 amplitudes and block numbers were observed at Cz and Pz in PD, and at Fz in the control group. Previous reports as well as present results suggest that prolongation of N100 latency might be related to frontal lobe dysfunction, and abnormality of P300 to dysfunction in both the frontal lobe and hippocampus in PD.

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Research articleEvent-related potentials in Parkinson's disease: A 12-month follow-up study

Abstract

Biol. Psychol.

Electroenceph. Clin. Neurophysiol.

Electroenceph. clin. Neurophysiol.

Electroenceph. clin. Neurophysiol.

Electroenceph. clin. Neurophysiol

Electroenceph. clin. Neurophysiol.

Brain Res.

Auditory evoked potentials (AEPs), early (BAEPs) and long latency components (LLCs) in Parkinson's disease: a 12 month follow-up study

Riv. Neurol.

Measurements of visual evoked potentials in Parkinson's disease

Brain

Is the P300 component a manifestation of context updating?

Behav. Brain Sci.

Unified Parkinson's Disease Rating Scale

Research article
Event-related potentials in Parkinson's disease: A 12-month follow-up study