Special articleThe local regulation of cerebral blood flow☆
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Cited by (83)
Design, synthesis and biological evaluation of Tozadenant analogues as adenosine A<inf>2A</inf> receptor ligands
2021, European Journal of Medicinal ChemistryCitation Excerpt :The purine nucleoside adenosine (adenine-9-β-d-ribofuranoside) is an ubiquitous but short-lived signaling molecule that exerts its effects through at least four subtypes of G-protein coupled adenosine receptors (ARs) [1]. Within the central nervous system (CNS), adenosine is a neuromodulator that participates in the regulation of sleep and arousal [2–4], is involved in cognition [5,6] and contributes to the autoregulation of cerebral blood flow [7,8]. The adenosine A2A receptor (A2AR) mediates multiple of the physiological effects of adenosine and has been implicated with a number of neurodegenerative [9,10], neuropsychiatric [11,12] and neuroinflammatory [13] disorders.
Receptor-Mediated Events in the Microcirculation
2008, MicrocirculationLocalization of equilibrative nucleoside transporters in the rat brain
2006, Journal of Chemical Neuroanatomy
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Supported in part by Grant HL10384 from NHLBI of the NIH and by the American Heart Association. H.R.W. is a recipient of Teacher-Investigator Award K07-N5004404.