Apolipoprotein &isin;4 homozygosity in young men with coronary heart disease

doi:10.1016/0140-6736(92)93288-X

The Lancet

Volume 340, Issue 8824, 10 October 1992, Pages 879-880

https://doi.org/10.1016/0140-6736(92)93288-X Get rights and content

Abstract

We have compared apolipoprotein E gene polymorphism in 91 Australian men aged 30-50 who had been referred for coronary angioplasty and in 172 healthy younger men. 5 of the 19 patients who were less than 40 years of age were homozygous for the ∈4 allele, representing a 16-fold increase in prevalence compared with controls. In patients aged 40-50 the ∈4 allele frequency was 60% higher than it was in controls. Inheritance of ∈4 seems to confer risk of premature ischaemic heart disease in males, homozygotes being especially at risk at a younger age.

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A statistically significant association was observed between GT and TT genotypes of endothelial nitric oxide synthase gene with CHD with OR = 2.03 and 3.5; respectively. Also, carriers of E4 allele and especially E3/E4 genotype were at higher risk of CHD with OR = 3.3 for both. Significant association was also observed between the presence of combined GTE3E4 genotype and CHD with OR = 6.6.
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Citation Excerpt :
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SHORT REPORTSApolipoprotein &isin;4 homozygosity in young men with coronary heart disease

Abstract

Atherosclerosis

J Lipid Res

Atherosclerosis

Apolipoprotein E polymorphism and atherosclerosis

Arteriosclerosis

Apolipoprotein E polymorphism and coronary artery disease

Arteriosclerosis

SHORT REPORTS
Apolipoprotein ∈4 homozygosity in young men with coronary heart disease