ArticlesX-chromosome effects on female brain: a magnetic resonance imaging study of Turner's syndrome
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2018, The Neurobiology of Brain and Behavioral DevelopmentMapping the effect of the X chromosome on the human brain: Neuroimaging evidence from Turner syndrome
2017, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Two studies have investigated this effect by comparing X-monosomy with mosaic TS individuals, in which mosaic TS was characterized by X-monosomy and another cell line presenting the second X chromosome, that is, the loss of the entire second X chromosome in only a proportion of their cells (Murphy et al., 1993; Xie et al., 2015). In their pioneering study, Murphy and colleagues reported significant volumetric differences in the left caudate nucleus and thalamus between mosaic and X-monosomy TS individuals (Murphy et al., 1993). More recently, Xie and colleagues identified a significant “dosage effect” (mosaic vs. X-monosomy) on cortical SA of the right angular gyrus and WM integrity of the left tapetum of the corpus callosum (Xie et al., 2015).