Endothelial cell expression of the intercellular adhesion molecule-1 (ICAM-1) in the central nervous system of guinea pigs during acute and chronic relapsing experimental allergic encephalomyelitis

https://doi.org/10.1016/0165-5728(90)90051-NGet rights and content

Abstract

This study investigated the expression of intercellular adhesion molecule-1 (ICAM-1; CD54) by cells of the central nervous system (CNS) during acute experimental allergic encephalomyelitis (EAE) and chronic relapsing EAE (CREAE). In the CNS of normal guinea pigs, only a few endothelial cells expressed detectable levels of ICAM-1, whereas during the active phases of the disease ICAM-1 was present on cells of the perivascular infiltrate and the endothelia of both lesion- and non-lesion-associated blood vessels. In addition, cultured cerebrovascular endothelia maintained in ‘standard’ culture medium did not express ICAM-1, but they could be induced to express this antigen on incubation in a lymphocyte-conditioned medium. These findings suggest that the induction of ICAM-1 on CNS endothelia may be important in antigen presentation or in promoting lymphocyte extravasation across the blood-brain barrier in inflammatory disorders of the CNS.

References (29)

  • P.C.L. Beverly et al.

    Identification of human naive and memory T cells

  • K.A. Brown et al.

    Immunological approaches to the understanding of multiple sclerosis

  • D.E. Cavender et al.

    Interleukin-1 increases the binding of human B and T lymphocytes to endothelial cell monolayers

    J. Immunol.

    (1986)
  • M.L. Dustin et al.

    Induction by IL-1 and interferon-γ: tissue distribution, biochemistry and function of a natural adherence molecule (ICAM0-1)

    J. Immunol.

    (1986)
  • Cited by (0)

    View full text