Elsevier

Behavioural Brain Research

Volume 41, Issue 2, 14 December 1990, Pages 81-94
Behavioural Brain Research

Research report
Individuals with sociopathic behavior caused by frontal damage fail to respond autonomically to social stimuli

https://doi.org/10.1016/0166-4328(90)90144-4Get rights and content

Abstract

Following damage to ventromedial frontal cortices, adults with previously normal personalities develop defects in decisionmaking and planning that are especially revealed in an abnormal social conduct. The defect repeatedly leads to negative personal consequences. The physiopathology of this disorder is an enigma. We propose that the defect is due to an inability to activate somatic states linked to punishment and reward, that were previously experienced in association with specific social situations, and that must be reactivated in connection with anticipated outcomes of response options. During the processing that follows the perception of a social event, the experience of certain anticipated outcomes of response options would be marked by the reactivation of an appropriate somatic state. Failure to reactivate pertinent somatic markers would deprive the individual of an automatic device to signal ultimately deleterious consequences relative to responses that might nevertheless bring immediate reward (or, alternatively, signal ultimately advantageous outcomes relative to responses that might bring immediate pain). As an example, activation of somatic markers would (1) force attention to future negative consequences, permitting conscious suppression of the responses leading to them and deliberate selection of biologically advantageous responses, and (2) trigger non-conscious inhibition of response states by engagement of subcortical neurotransmitter systems linked to appetitive behaviors. An investigation of this theory in patients with frontal damage reveals that their autonomic responses to socially meaningful stimuli are indeed abnormal, suggesting that such stimuli fail to activate somatic states at the most basic level. On the contrary, elementary unconditioned stimuli (e.g. a loud noise) produce normal autonomic responses.

References (56)

  • T. Shallice et al.

    The involvement of the frontal lobes in cognitive estimation

    Cortex

    (1978)
  • D. Tranel et al.

    Non-conscious face recognition in patients with face agnosia

    Behav. Brain Res.

    (1988)
  • D. Tranel et al.

    Intact electrodermal skin conductance responses in a patient with bilateral amygdala damage

    Neuropsychologia

    (1989)
  • G.W. Van Hoesen et al.

    Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey: II. Frontal lobe afferents

    Brain Res.

    (1975)
  • D.G. Amaral et al.

    Amygdalo-cortical projections in the monkey (Macaca fascicularis)

    J. Comp. Neurol.

    (1984)
  • American Psychiatric Association
  • D. Bear et al.

    Increased autonomic responses to neural and emotional stimuli in patients with temporal lobe epilepsy

    Am. J. Psychiatry

    (1981)
  • A.L. Benton
  • A.S. Bernstein

    The orienting response as novelty and significance detector: reply to O'Gorman

    Psychophysiology

    (1979)
  • W. Boucsein

    Elektrodermale aktivitat: Grundlagen, methoden und anwendungen

    (1988)
  • W.B. Cannon

    The James-Lange theory of emotions: a critical examination and an alternative theory

    Am. J. Psychol.

    (1927)
  • C. Clugnet et al.

    Short latency orthodromic action potentials evoked in amygdala and caudate-putamen by stimulation of the medial geniculate body

    Soc. Neurosci. Abstr.

    (1988)
  • A.R. Damasio

    The brain binds entities and events by multiregional activation from convergence zones

    Neural Computation

    (1989)
  • H. Damasio et al.

    Lesion analysis in neuropsychology

    (1989)
  • R. Edelberg

    The electrodermal system

  • R. Edelberg

    Mechanisms of electrodermal adaptations for locomotion, manipulation, or defense

    Progr. Physiol. Psychol.

    (1973)
  • P.J. Eslinger et al.

    Severe disturbance of higher cognition after bilateral frontal lobe ablation: patient EVR

    Neurology

    (1985)
  • C.F. Farb et al.

    Projections from the acoustic thalamus terminate in the lateral but not central amygdala

    Soc. Neurosci. Abstr.

    (1988)
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