TrendTCR usage in human and experimental demyelinating disease
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Cited by (106)
T-cell repertoire profiling by next-generation sequencing reveals tissue migration dynamics of TRBV13-family clonotypes in a common experimental autoimmune encephalomyelitis mouse model
2019, Journal of NeuroimmunologyCitation Excerpt :In the MBP model, there is a strong overlap of the encephalitogenic epitopes between mice and humans (Sospedra and Martin, 2005). Moreover, V-gene restriction of myelin reactive T-cells leading to an oligoclonal T-cell repertoire has been especially found in MBP-induced mouse models (Acha-Orbea et al., 1988; Urban et al., 1988), a phenomenon that is also observed in MS patients (Hafler et al., 1996; Planas et al., 2018). Based on these findings, specific TCR directed therapies targeting the restricted repertoire were developed, although with little success (Killestein et al., 2002; Vandenbark et al., 2008; Wraith, 2009).
Clonal composition of neuroantigen-specific CD8+ and CD4+ T-cells in multiple sclerosis
2011, Journal of NeuroimmunologyCitation Excerpt :Therefore, while we did not observe specific TCRBV usage differences in the CNS-specific CD8+ T-cell responses between healthy subjects vs. MS patients, just the differences in the clonal distribution may potentially indicate the lack of an important regulatory CD8+ T-cell subset in baseline MS. While prior studies have found some global CDR3 distribution differences in CD8+ T-cells in MS patients vs. healthy subjects (Laplaud et al., 2004), this difference does not seem to represent CNS-specific CD8+ T-cells. These findings correlate with a previous study finding little or no difference in the clonal composition of myelin antigen-reactive T-cells between MS patients and healthy subjects (Hafler et al., 1996). Possibly a more detailed breakdown of the CD8+ T-cell population would provide more insights, such as one performed by Somma et al., where they found a skewed repertoire in 3 pairs of MS discordant twins when they divided the CD8+ T-cell fraction into CCR7 negative (effector memory) and CCR7 positive (central memory, naïve) fractions (Somma et al., 2007).
Astrocytic β<inf>2</inf>-adrenergic receptors and multiple sclerosis
2004, Neurobiology of DiseaseActivation pathways that drive CD4<sup>+</sup> T cells to break tolerance in autoimmune diseases*
2022, Immunological ReviewsProtective Effects on Central Nervous System by Acidic Polysaccharide of Panax ginseng in Relapse-Remitting Experimental Autoimmune Encephalomyelitis-Induced SJL/J Mice
2016, American Journal of Chinese Medicine
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The 1st International Workshop on T-cell Receptor Usage in Human and Experimental Demyelineting Disease' was held at Leiden, The Netherlands, on 28 October 1994.