Trial to establish an animal model of paraneoplastic cerebellar degeneration with anti-Yo antibody: 1. Mouse strains bearing different MHC molecules produce antibodies on immunization with recombinant Yo protein, but do not cause Purkinje cell loss
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2011, Revue NeurologiqueCitation Excerpt :Indeed, in vivo experiments after injection in rats or mice brain of human ONA such as anti-Yo or anti-Hu causes no neurological abnormality (Sillevis Smitt et al., 1995, Tanaka et al., 1995). Similarly, immunization of rodents with purified Yo or Hu antigens leads to the production of antibodies against these proteins, but does not cause neurological symptoms (Tanaka et al., 1995). Following this work, many authors have assumed that cellular immunity was the main actor in the neurological damages of these patients and that the ONA were only markers of immune response.
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2011, Clinical Neurology and NeurosurgeryCitation Excerpt :An important question is why paraneoplastic RT is rare, given that no case of tremor was reported in a large previous study of 55 patients positive for anti-Yo autoantibody [4]. Passive transfer of anti-Yo-autoantibody does not induce Purkinje cell loss in animals, suggesting the involvement of other factors, such as host-related factors [5]. Tanaka et al. found that anti-Yo-autoantibody-positive paraneoplastic syndrome is closely associated (100% [9 of 9 patients]) with HLA-A24, a common MHC class I antigen in Japan (∼60%) [5].
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