Selected area membrane shedding by tumor cells

doi:10.1016/0304-3835(83)90040-X

Cancer Letters

Volume 20, Issue 2, September 1983, Pages 125-130

https://doi.org/10.1016/0304-3835(83)90040-X Get rights and content

Abstract

Isolated plasma membranes and naturally shed plasma membrane vesicles from cultured human breast cancer cells were examined by electron microscopy and enzyme analysis. Alkaline phosphatase activity and cytotoxic antibody binding were increased in vesicles as compared to membranes. The activities of γ-glutamyl transpeptidase (GGTP) and protein kinase were high in membranes and low or absent in vesicles. The observed differences between the plasma membrane and the naturally shed plasma membrane vesicles suggest that the vesicles are micromaps of selected parts of the plasma membrane. These membrane micromaps may allow the tumor cell to avoid destruction by the host's immune system.

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Research letterSelected area membrane shedding by tumor cells

Abstract

J. Biol. Chem.

Clin. Chim. Acta

Exp. Cell Res.

Biochem. Biophys. Res. Commun.

Cancer Letters

Biochim. Biophys. Acta

Blood-group like activity releasd by human mammary carcinoma cells in culture

Nature

Shedding from the cell surface of normal and cancer cells

Adv. Cancer Res.

Antibody-induced modulation and shedding of tumor virus antibody-induced modulation and shedding of tumor virus antigens on the surface of GR ascites leukemia cells as compared with normal antigens

J. Natl. Caricer Inst.

Research letter
Selected area membrane shedding by tumor cells