Elsevier

Neuroscience Letters

Volume 135, Issue 2, 3 February 1992, Pages 235-238
Neuroscience Letters

Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid

https://doi.org/10.1016/0304-3940(92)90444-CGet rights and content
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Abstract

Many biochemically diverse proteins can give rise to amyloid fibrils; however, they are all accompanied by P component and glucosaminoglycans. With antibodies specific to apolipoprotein E (apo E) we used immunohistochemical techniques to test for the presence of this protein in both cerebral and systemic amyloid. We found apo E immunoreactivity in all tested types of cerebral and systemic amyloid. In amyloid deposits apo E P, component and glucosaminoglycans may be acting as ‘pathological molecular chaperones’. The latter we define as a group of unrelated proteins that induce β-pleated conformation in amyloidogenic polypeptides.

Keywords

Apolipoprotein E
Cerebral amyloid
Systemic amyloid
Immunohistochemical technique

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