Elsevier

Neuroscience Letters

Volume 186, Issues 2–3, 17 February 1995, Pages 189-191
Neuroscience Letters

Increased cerebrospinal fluid tau in patients with Alzheimer's disease

https://doi.org/10.1016/0304-3940(95)11297-AGet rights and content

Abstract

One of the pathological features in Alzheimer's disease (AD) is neurofibrillary tangles in the brain. The main constituent of tangles is the microtubuli-associated protein tau in a hyperphosphorylated state. Tau is also released into cerebrospinal fluid (CSF), and in this study we have used an enzyme linked immunosorbent assay to measure tau in CSF from AD and control cases. Our findings show that tau levels in AD cases are significantly elevated compared to healthy control individuals. We suggest that tau may serve as a biochemical marker of Alzheimer's disease.

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Cited by (0)

1

We wish to thank Dr. Bengt Winblad for generous support, Dr. Thomas Olsson for providing the CSF samples from control individuals and other neurological diseases, and Drs. Eugeen Vanmechelen and Dale Schenk for their valuable comments on the manuscript. The following foundations are acknowledged: Torsten och Ragnar Söderberg, The Bank of Sweden Tercentenary Foundation, Tore Nilsson, Groschinsky, Axelsson-Johnsson, Golje, Martin Rind, Osterman, Söderström-König, Magnus Bergvall, Gamla Tjänarinnor, the Alzheimer foundation and the Swedish Medical Research Council (project no. 10819).

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