Research paperHippocampal age-related changes in schizophrenia: a proton magnetic resonance spectroscopy study
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Supplementation of antipsychotic treatment with sarcosine - G1yT1 inhibitor - causes changes of glutamatergic <sup>1</sup>NMR spectroscopy parameters in the left hippocampus in patients with stable schizophrenia
2015, Neuroscience LettersCitation Excerpt :In schizophrenia, there is less spectroscopic data concerning the hippocampus than the prefrontal cortex and the anterior cingulate gyrus. In the studies on the hippocampus, patients in chronic phase of the disease, had reducted NAA concentrations [14,24–30] and NAA/Cr ratio [31–37]. On the other hand, results of other studies did not show significant changes in these parameters in comparison to healthy controls [38–41].
T<inf>2</inf> relaxation effects on apparent N-acetylaspartate concentration in proton magnetic resonance studies of schizophrenia
2013, Psychiatry Research - NeuroimagingNeurometabolites in schizophrenia and bipolar disorder - A systematic review and meta-analysis
2012, Psychiatry Research - NeuroimagingProton magnetic resonance spectroscopy and illness stage in schizophreniaa systematic review and meta-analysis
2011, Biological PsychiatryCitation Excerpt :This result was similarly the only outlier for this region and patient group. For chronic patients, the only outlier in temporal lobe was the left hemisphere subgroup from Maier and Ron (98). One possible explanation is that the patients and control subjects in this study were not well-matched in terms of age; the patients being significantly older.
Macroscopic brain asymmetry is changed along the antero-posterior axis in schizophrenia
2005, Schizophrenia ResearchCitation Excerpt :The corpus callosum expands in an antero–posterior direction during development (Giedd et al., 1996), and foetal brain dissections show increasing brain growth occipitally, with concomitant extension of the corpus callosum posteriorly (e.g., see Feess-Higgins and Larroche, 1987). Slower development has been reported for the left hemisphere compared to the right (Maier and Ron, 1996). This evidence suggests that, as development proceeds from front to back within the hemispheres, the slower rate of development on the left normally results in a greater proportion of left hemisphere growth occurring posteriorly.
Possible contributions of myelin and oligodendrocyte dysfunction to schizophrenia
2004, International Review of Neurobiology