Elsevier

Seizure

Volume 1, Issue 3, September 1992, Pages 183-185
Seizure

Original article
Does chloroquine cause seizures? Presentation of three new cases and a review of the literature

https://doi.org/10.1016/1059-1311(92)90023-TGet rights and content

Abstract

Three cases are reported of patients developing seizures whilst taking chloroquine. Recently, eight such cases have been reported elsewhere. A review of all patients described in the literature is given. Possible relationships between chloroquine and the occurrence of seizures are discussed and further studies recommended. At present we feel there is no need to restrict prescription of chloroquine to patients with a history of epilepsy.

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There are more references available in the full text version of this article.

Cited by (19)

  • Possible involvement of nitrergic and opioidergic systems in the modulatory effect of acute chloroquine treatment on pentylenetetrazol induced convulsions in mice

    2016, Brain Research Bulletin
    Citation Excerpt :

    Experimental studies reported NO as a neuromodulator with proconvulsive or anticonvulsive properties, depending on the convulsion models. In some case reports, possible stimulatory effects of chloroquine on seizures were discussed (Luijckx et al., 1992; Torrey, 1968). Moreover, in the chloroquine adverse effects profile, convulsions and also non convulsive status epilepticus have been mentioned (Fish and Espir, 1988; Mülhauser, 1995).

  • Does mefloquine prophylaxis affect electroencephalographic patterns?

    2002, American Journal of Medicine
    Citation Excerpt :

    We previously reported that mefloquine blood levels were not correlated with other serious adverse effects of mefloquine (22). An association between antimalarial medications and seizures has been noted with chloroquine as well (23–25). It may be a result of high concentrations of the drug in the cerebrospinal fluid, intracellular accumulation of the drug, genetic predisposition, or coadministration of other drugs (10).

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