Elsevier

Biological Psychiatry

Volume 41, Issue 7, 1 April 1997, Pages 804-809
Biological Psychiatry

Decreased cholecystokinin levels in cerebrospinal fluid of patients with adult chronic hydrocephalus syndrome

https://doi.org/10.1016/S0006-3223(96)00098-4Get rights and content

Cholecystokinin (CCK) levels were measured in cerebrospinal fluid (CSF) of patients with adult chronic hydrocephalus syndrome (ACHS) (n = 16) and compared with levels from a control group (n = 11). The CSF concentration of CCK in the ACHS group (0.79 ± 0.53 fmol/mL) was significantly reduced (p = .002) with respect to the controls (1.55 ± 0.54 fmol/mL). As CCK-8, the most prevalent form of CCK in the central nervous system, has been demonstrated to play a significant role in several physiological and behavioral actions, the reduced octapeptide values found in ACHS could be involved in the disturbances associated with this disorder. Continuous monitoring of intracranial pressure (ICP) demonstrated different ICP profiles in ACHS. We found that all patients with abnormal ICP records except one showed CCK values under the detection limit. Three of the 4 patients with normal ICP had CCK levels within the normal range. These preliminary studies could evidence that ICP alterations are responsible for part of the loss of brain neuropeptide levels in ACHS.

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      The remaining 14 genes are not currently known to be associated with the presence or development of hydrocephalus. Cholecystokinin (Cck) was downregulated 1.71-fold in our hydrocephalic animals relative to control animals and clinical studies have shown Cck levels decrease in adult patients with hydrocephalus (Galard et al., 1997). Cck is known to be involved in learning and memory, and hydrocephalic children have been shown to exhibit learning and memory deficits when compared to non-hydrocephalic children of the same age (Ding et al., 1999).

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    This work was supported in part by a grant from the Fondo de Investigaciones Sanitarias de la Seguridad Social -FISS- (92/1314), Ministerio de Educación y Ciencia, Spain.

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