Original articleMinor anomalies in offspring of epileptic mothers*
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Cited by (118)
Drugs and Environmental Agents in Pregnancy and Lactation: Teratology, Epidemiology
2016, Obstetrics: Normal and Problem PregnanciesNeurologic Disorders in Pregnancy
2016, Obstetrics: Normal and Problem PregnanciesImpact of early life exposure to antiepileptic drugs on neurobehavioral outcomes based on laboratory animal and clinical research
2013, Epilepsy and BehaviorCitation Excerpt :Some of the earliest studies to identify a potential effect of AEDs on cognitive function in the offspring come from studies of phenytoin, where it was shown that there was an increased risk to cognitive function following prenatal exposure [19,24]. These findings were, in part, confirmed by follow-up studies in which trends were found toward decreased IQ in children (aged 4, 5, and 7 years) exposed to phenytoin in utero [20,34,80–85]. In a significant proportion of those studies, phenytoin was used as part of a polytherapy, so the direct contribution of phenytoin to cognitive outcomes could not be assessed.
Neurodevelopmental effects of anti-epileptic drugs
2010, Epilepsy ResearchCitation Excerpt :A possible increased risk of developmental delay in offspring born to mothers with epilepsy taking anti-epileptic drugs has long been noted, but not attributed to any specific anticonvulsant. ( Gaily et al., 1988; Granstrom and Gaily, 1992; Speidel and Meadow, 1972). Many potential contributory factors have been considered such as maternal seizure type, number of seizures during pregnancy, IQ and education of parents, in addition to AED exposure (Table 1).
Risk of major congenital malformations in the offsprings of women with epilepsy is not related to family history
2009, Epilepsy ResearchCitation Excerpt :A genetic predisposition to malformations may also be operating as only less than ten percent of infants exposed to AEDs in utero develop malformations. Earlier studies had suggested that some of the minor dysmorphic features observed in the offsprings of WWE could have a genetic basis (Gaily et al., 1988). Studies that focused on genetic liability to malformation when mother has epilepsy have been few in the past, although a causal relationship had been raised in some of the earlier papers (Meadow, 1970).
Motor and mental development of infants exposed to antiepileptic drugs in utero
2008, Epilepsy and Behavior
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Supported by the Rinnekoti Research Foundation, Espoo, Finland, the Foundation for Pediatric Research, and the Orion Foundation.
Preliminary results presented in part at the 16th Epilepsy International Congress, Hamburg, Sept. 6–9, 1985 (published in: Wolf P, Dam M, Jane D, Dreifuss FE, eds. Advances in epileptology; vol. 16. New York: Raven Press, 1987;567–71).