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Sleep, respiration and ALS

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Cited by (19)

  • Effects of exercise on sleep in neurodegenerative disease

    2020, Neurobiology of Disease
    Citation Excerpt :

    Insomnia (65%) and sleep-disordered breathing (52.5%) were the two most common sleep disorders reported in one observational study (Lo Coco et al., 2011). These disturbances are due to an extended range of considerations including nocturnal hypoventilation, restless legs syndrome, obstructive sleep apnea, difficulty positioning in bed due to lack of mobility, cramps, depressed mood, psychological stress, excessive secretions, and choking (Hetta and Janssson, 1997; Aboussouan and Lewis, 1999; Ahmed et al., 2016). Nocturnal hypoventilation results from weakness of respiratory, bulbar, or diaphragmatic musculature, a challenge which is likely intensified by supine posture and failure of accessory respiratory muscle function during REM sleep.

  • Sleep and Neurologic Problems in the Elderly

    2006, Sleep Medicine Clinics
    Citation Excerpt :

    Degeneration of the central respiratory neurons accounts for both central sleep apnea and OSA. Polysomnographic findings include apneas in the form of central, obstructive, and mixed events; increased awakenings; sleep fragmentation; and reduced nocturnal oxygen saturation [158,159,162–164]. Noninvasive positive pressure upper airway ventilation provides a long-lasting benefit on symptoms and quality of life indicators for amyotrophic lateral sclerosis patients and should be offered to all patients with symptoms of SDB or inspiratory muscle dysfunction [165].

  • Survival in amyotrophic lateral sclerosis with home mechanical ventilation: The impact of systematic respiratory assessment and bulbar involvement

    2005, Chest
    Citation Excerpt :

    One explanation for the absence of differences in survival times may be the initiation of NIV based on symptoms or alterations secondary to bulbar musculature dysfunction more than respiratory musculature involvement. Nocturnal symptoms such as dyspnea, awakening, choking episodes, or nocturnal desaturations may correspond to deglutitory disorders20 or to obstruction of the upper airway,21 and the specific diagnosis of these alterations may require more complex studies such as polysomnography.22 On the other hand, the suggestion by other authors23 that the lesser the bulbar involvement, the more probable the adaptation to NIV therapy may have influenced the earlier initiation of therapy in this group of patients in whom greater benefits were observed, although our results do not appear to confirm this hypothesis.

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