Elsevier

The Lancet

Volume 348, Issue 9030, 21 September 1996, Pages 829-830
The Lancet

Letters to the Editor
Neuroimaging and early Alzheimer's disease

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    Given that the hippocampus plays a pivotal role in specific aspects of memory and learning, declining cognitive performance in association with obesity might plausibly be linked to changes in hippocampus volume [11,12]. Among community-living healthy older people, the hippocampal volume normally declines with age [13,14]. The changes are nonetheless important because preclinical cognitive impairments correlate with smaller hippocampal size [15,16].

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