Elsevier

The Lancet

Volume 345, Issue 8965, 24 June 1995, Pages 1609-1610
The Lancet

Cerebrospinal fluid concentration of neuron-specific enolase in diagnosis of Creutzfeldt-Jakob disease

https://doi.org/10.1016/S0140-6736(95)90118-3Get rights and content

Abstract

Neuron-specific enolase (NSE) is among the biochemical markers in cerebrospinal fluid reported to be useful in the differential diagnosis of Creutzfeldt-Jakob disease from other dementing illnesses. In a group of 58 patients with definite and probable Creutzfeldt-Jakob disease, NSE concentrations (median 94·0, interquartile range 256 ng/mL) were significantly higher (p<0·001) than in 26 control patients (9·5, 15·5 ng/mL). At a cut-off of 35 ng/mL an optimum sensitivity of 80% with a specificity of 92% for the diagnosis of Creutzfeldt-Jakob disease by NSE in cerebrospinal fluid was obtained.

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