Elsevier

Neuroscience Letters

Volume 335, Issue 2, 25 December 2002, Pages 75-78
Neuroscience Letters

No association of the HLA-A2 allele with Alzheimer's disease

https://doi.org/10.1016/S0304-3940(02)01057-1Get rights and content

Abstract

A possible association of the human leucocyte antigen (HLA)-A2 allele with increased susceptibility to Alzheimer's disease (AD) has been the subject of debate for more than 20 years. We compared the presence of the HLA-A2 allele in a sample from the French population composed of 451 patients and 477 controls. There was no evidence of an association of this allele with increased risk of AD. Moreover, no effect was observed when we stratified the case-control sample on gender, age of onset or presence of an APOE ε4 allele. We conclude that HLA-A2 allele is not a major risk factor for sporadic AD.

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Acknowledgements

A.G.L. is a recipient of the Region Nord Pas de Calais-Pasteur Lille Fellowship. This work was supported by the Institut National pour la Santé et la Recherche Médicale (INSERM), the Institut Pasteur de Lille, the Conseil Régional du Nord-Pas de Calais ‘Funds for Neurodegenerative Research’ (Arrété 9926002).

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